Baltimore Orioles vs Detroit Tigers Prediction 4/25/25 MLB Picks

The Baltimore Orioles and the Detroit Tigers meet Monday in MLB action from Comerica Park. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Baltimore Orioles vs. Detroit Tigers prediction.

Starting Pitching Matchup

The Baltimore Orioles will send out Brandon Young for the start here and Young is 0-0 with a 6.75 ERA and 3 strikeouts this season. This will be Young’s first career start against the Tigers. Casey Mize will get the start for the Tigers here and is 3-1 with a 2.22 ERA and 18 strikeouts this season. In his career, Mize is 1-0 with a 2.38 ERA and 6 strikeouts against Baltimore.

Baltimore Orioles Recap

The Baltimore Orioles come into this game looking to build on their 2-1 win over the Washington Nationals in Thursday’s series finale to improve to 10-14 on the year. After this series, the Orioles will head home for a divisional series against the Yankees.

Orioles Snap Three-Game Losing Skid & Salvage Win Vs. Nationals.

Cedric Mullins has a team-high 23 hits so far this season as well as team-highs of 5 doubles, 6 home runs and 20 RBIs with 5 stolen bases and a .295 batting average while Adley Rutschman has 18 hits with a pair of doubles, 4 homers and 8 RBIs. Ryan Mountcasle has 17 hits with 4 doubles and Tyler O’Neill has 14 hits with 3 doubles, a triple and 2 homers with 10 RBIs. Jordan Westburg’s added 4 home runs and Gunnar Henderson has a team-high 23 strikeouts as well this season.

Why the Baltimore Orioles will win

• The Tigers have lost each of their last nine night games against the Orioles at Comerica Park following a home win.
• The Orioles have won seven of their last eight games as road underdogs against AL Central opponents following a road win.
• The Tigers have failed to cover the run line in each of their last nine night games against the Orioles at Comerica Park following a home win.
• The Orioles have covered the run line in seven of their last eight games as underdogs against AL Central opponents following a road win.

Baltimore Orioles Player Prop Facts

• Ryan O’Hearn has hit a home run in four of the Orioles’ last five night games against opponents that held a winning record.
• Gary Sanchez has recorded an RBI in each of his last four appearances against AL opponents that held a winning record.
• Jorge Mateo has recorded a Double in three of his last four appearances against AL Central opponents that held a winning record.
• Ryan Mountcastle has recorded at least one hit in each of his last nine road appearances against AL opponents that held a winning record.
• Ryan Mountcastle has recorded at least one Single in each of his last eight road appearances against AL opponents that held a winning record.
• Jorge Mateo has scored a run in each of his last six appearances against the Tigers.
• Cedric Mullins ranks 5th amongst qualified players for On Base Percentage (.433) this season.

Detroit Tigers Recap

The Detroit Tigers come into this series looking to build on their 6-0 win over the San Diego Padres from Wednesday’s series finale to improve to 15-10 on the year. After this series, the Tigers will head on the road for a series against the Houston Astros.

Tigers Win Second Straight Series

Spencer Torkelson leads the Tigers with 24 hits along with a .264 batting average including a team-high 7 home runs, 7 doubles and 21 RBIs. Kerry Carpenter also has 5 home runs and 11 RBIs while Riley Greene has 22 hits with 4 doubles, 3 home runs and 10 RBIs but also has a team-high 34 strikeouts as well this season. Trey Sweeney also has 15 hits with 2 doubles, a triple and a home run and 8 RBIs. Dillon Dingler has 3 home runs and 11 RBIs and Zack McKinstry’s added 3 triples, a home run and 12 RBIs of his own along with 23 hits as well this season.

Why the Detroit Tigers will win

• The Tigers have won 12 of their last 13 night games against American League opponents that held a losing record.
• The Orioles have lost nine of their last 10 games following a win.
• The Tigers have covered the run line in each of their last eight night games against American League opponents.
• The Orioles have failed to cover the run line in nine of their last 10 games following a win.

Detroit Tigers Player Prop Facts

• Spencer Torkelson has hit a home run in two of the Tigers’ last three games as favorites against AL East opponents.
• Riley Greene has recorded a Double in each of his last five Friday appearances with the Tigers as favorites.
• Casey Mize has recorded a win in three of his last four appearances.
• Spencer Torkelson has recorded at least one RBI in seven of the Tigers’ last eight home games against opponents that held a losing record.
• Spencer Torkelson has scored at least one run in eight of the Tigers’ last nine games against AL opponents.
• Gleyber Torres has recorded at least one Single in each of his last 10 appearances against AL East opponents that held a losing record.
• Parker Meadows has recorded at least one hit in each of his last 13 appearances in night games.
• Casey Mize ranks T5th in the league for Wins (3) this season.

Total Runs Facts

• Seven of the Tigers’ last eight games as favorites against AL East opponents have gone UNDER the total runs line.
• Six of the Orioles’ last seven night games against AL Central opponents have gone OVER the total runs line.

Baltimore Orioles vs. Detroit Tigers Prediction

I’m on the Tigers here. I just didn’t love what I saw from Young in his major league debut, and the Tigers are rolling offensively right now, and have been crushing teams at home this season. The Orioles I think were lucky to salvage a win from their series with Washington to start the week, and I don’t think they’ll be as fortunate here with how the Tigers are rolling along and how well Mize has pitched to this point. Give me Detroit at home in this one.