Baltimore Orioles vs Chicago White Sox Prediction 9/15/2025 Today’s MLB Picks

The Baltimore Orioles and the Chicago White Sox meet Monday in MLB action from Rate Field. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Baltimore Orioles vs. Chicago White Sox prediction.

Starting Pitching Matchup

The Baltimore Orioles will send out Kyle Bradish for hte start and Bradish is 0-1 with a 2.65 ERA and 21 strikeouts this season. This will be Bradish’s second career start against the White Sox. The Chicago White Sox did not have a starting pitcher announced at the time that this article was posted.

Baltimore Orioles Recap

The Baltimore Orioles come into this game looking to rebound from an 11-2 loss at the hands of the Toronto Blue Jays last time out to sit at 69-80 this season. After this series, the Orioles will head home for a series against the New York Yankees.

Orioles Drop Three Straight

Adley Rutschman has 70 hits with 16 doubles, 9 homers and 29 RBIs. Jackson Holliday has 138 hits with 20 doubles, 3 triples, 17 homers and 55 RBIs. Gunnar Henderson has 143 hits with 32 doubles, 5 triples, 16 home runs and 62 RBIs with 23 stolen bases and 128 strikeouts while Holliday has a team-high 130 strikeouts as well this season. 

Chicago White Sox Recap

The Chicago White Sox come into this game looking to bounce back from their 3-2 loss at the hands of the Cleveland Guardians on Sunday to drop to 57-93 this season. After this series, the White Sox will take on the San Diego Padres in an interleague series at home.

White Sox Lose Three In A Row

Lenyn Sosa has 126 hits including 18 doubles, 20 home runs and 68 RBIs. Andrew Benintendi has 100 hits including 16 doubles, 19 home runs, 60 RBIs and a .241 batting average while Miguel Vargas has 107 hits, 31 doubles, 14 home runs and 53 RBIs. Brooks Baldwin has also added 31 RBIs while Luis Robert Jr. has a team-high 33 stolen bases along with 53 RBIs so far this season. Chase Meidroth has added 108 hits with 13 stolen bases as well as 15 doubles this season.

Baltimore Orioles @ the Chicago White Sox Betting Trends: September 15, 2025

• Probable Starting Pitcher: TBD

Why the Chicago White Sox will win

• The Orioles have lost each of their last seven games against American League opponents.
• The home team has won each of the Orioles’ last six games.
• The White Sox have covered the run line each of their last eight games against teams that held a losing record.
• The Orioles have failed to cover the run line in each of their last seven games as favorites against American League opponents.
• The White Sox have led after 3 innings in four of their last five home games against opponents that held a losing record.
• The Orioles have trailed after 5 innings in five of their last six night games against AL Central opponents that held a losing record.
• The Orioles have lost the first inning in each of their last four road games against opponents that held a losing record.

• Probable Starting Pitcher: Kyle Bradish      Record this season: 0-1      ERA: 2.65
• Road Record: 0-0
• Last 5 against White Sox: 1-0

Why the Baltimore Orioles will win

• The White Sox have lost 15 of their last 16 night games against American League opponents following a road loss.
• The Orioles have won nine of their last 10 games against the White Sox.
• The Orioles have covered the run line in 12 of their last 13 games at Rate Field against teams that held a losing record.
• The White Sox have failed to cover the run line in each of their last six home games following a road loss.
• The White Sox have trailed after 3 innings in each of their last four night games against AL East opponents that held a losing record.
• The White Sox have trailed after 5 innings in each of their last four night games against AL East opponents that held a losing record.

Total Runs Facts

• Each of the White Sox’s last four games have gone UNDER the total runs line.
• Each of the Orioles’ last four night games against American League opponents have gone UNDER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Orioles’ last six games as favorites.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in seven of the White Sox’s last eight games against AL East opponents.

Chicago White Sox Player Prop Facts

• Mike Tauchman has hit a home run in two of his last three appearances against the Orioles after playing the previous day.
• Andrew Benintendi has recorded at least one hit in each of his last nine home appearances.

Baltimore Orioles Player Prop Facts

• Tyler O’Neill has hit a home run in four of his last five appearances with the Orioles as favorites.
• Kyle Bradish has recorded six or more strikeouts in each of his last eight appearances with the Orioles as road favorites.
• Gunnar Henderson has recorded at least one hit in each of the Orioles’ last 10 games as favorites against AL opponents.
• Kyle Bradish has recorded a win in five of his last six appearances with the Orioles as road favorites against AL opponents.
• Ryan Mountcastle has recorded a Double in three of the Orioles’ last four road games against the White Sox.

Matchup/League Facts

• The White Sox rank 29th in the league for walks allowed this season (551).
• The White Sox rank 28th in the league for slugging percentage this season (.375).
• The Orioles rank 28th in the league for opponent batting average this season (.261).
• The Orioles rank 28th in the league for hits allowed this season (1333).

Baltimore Orioles vs. Chicago White Sox Prediction

I’m on the Orioles here. I get the case to be made for either side in this game, but I do really like what I’ve seen from Kyle Bradish in his limited action since returning from injury. It would be nice to know who the White Sox are putting out here, but I feel like the Orioles’ offense in this spot has more upside and I think the Orioles get the job done here. Give me Baltimore in this one.