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Athletics vs Seattle Mariners Prediction 4/22/2026 Today’s MLB Picks

Apr 15, 2026; San Diego, California, USA; Seattle Mariners left fielder Randy Arozarena hits a single during the fifth inning against the San Diego Padres at Petco Park. All MLB players are wearing number 42 today to honor Jackie Robinson. Mandatory Credit: Denis Poroy-Imagn Images

Apr 15, 2026; San Diego, California, USA; Seattle Mariners left fielder Randy Arozarena hits a single during the fifth inning against the San Diego Padres at Petco Park. All MLB players are wearing number 42 today to honor Jackie Robinson. Mandatory Credit: Denis Poroy-Imagn Images

MATCHUP Oakland Athletics Seattle Mariners
Team Records 13-11 10-15
Where T-Mobile Park, Seattle, Washington
When Wednesday, April 22, 2026
Time 04:10 PM EDT
TV MLB.TV

The Athletics and the Seattle Mariners meet Wednesday in MLB action from T-Mobile Park. We will look at this from a betting perspective and determine the best bets for this game. Here’s an Athletics vs. Seattle Mariners prediction.

Starting Pitching Matchup

The Athletics will send out Aaron Civale for the start here and Civale is 2-1 with a 3.54 ERA and 16 strikeouts this season. Logan Gilbert will get the start for the Mariners and is 1-3 with a 4.03 ERA and 32 strikeouts this season.

Athletics Recap

The Athletics come into this game looking to add on to their 5-2 win over the Mariners from Tuesday’s matchup to sit at 13-11 this season. After this series, the Athletics will head on the road for a series against the Texas Rangers.

A’s Pushing For Sweep

Going into Tuesday, Shea Langeliers has 27 hits with 4 doubles, 7 home runs and 13 RBIs while Tyler Soderstrom’s added 19 hits with 7 doubles, a triple, 2 home runs and 15 RBIs. Brent Rooker has 6 hits with 2 home runs and 8 RBIs while Max Muncy has also chipped in 20 hits with 5 doubles, 2 triples, 2 home runs and 7 RBIs this season. Jacob Wilson also has 25 hits with 3 doubles, 2 home runs and 10 RBIs this season.

Seattle Mariners Recap

The Seattle Mariners come into this game looking to bounce back from their loss at the hands of the Athletics on Tuesday to sit at 10-15 this season. After this series, the Mariners will head on the road for a series against the St. Louis Cardinals.

Mariners Drop Back-To-Back Games

Entering Tuesday, Brendan Donovan has 17 hits with 3 doubles, 3 home runs and 8 RBIs while Luke Raley has 5 home runs and 13 RBIs this season. Cole Young’s added 20 hits with 2 doubles, a triple, 2 home runs and 11 RBIs and Cal Raleigh has 15 hits with 3 doubles, 3 home runs and 12 RBIs as well this season. Randy Arozarena has 24 hits with 5 doubles, 2 home runs and 9 RBIs as well on the year. Josh Naylor also has 15 hits with 2 home runs and 8 RBIs as well on the year. 

Athletics @ Seattle Mariners Betting Trends: April 22, 2026

Why the Seattle Mariners will win

Why the Athletics will win

Total Runs Facts

Seattle Mariners Player Prop Facts

Athletics Player Prop Facts

Matchup/League Facts

Athletics vs. Seattle Mariners Prediction

I’m on the Athletics in this one. Gilbert has been solid at home over the course of his career, but I’m still having trouble trusting the Mariners offense at the plate this season. I’m not necessarily president of the Aaron Civale fan club, but I think he’s a capable option that can pitch well away from Sacramento like a lot of A’s pitchers have with this new ballpark. Give me the Athletics here.

Chris Ruffolo's Pick: Athletics +1.5

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