Astros vs White Sox Prediction 5/4/25 MLB Picks

In this article, we will formulate an Astros vs White Sox prediction for this MLB game on Sunday, May 4th at Rate Field in Chicago, Illinois. Let’s take a look at the prediction for this MLB matchup. 

Houston Astros Betting Preview

The Houston Astros are 17-15 this season after they won game two by a score of 8-3 on Saturday afternoon. Houston trailed 3-0 early in the game, but they scored the last eight runs for the easy win. The Astros recorded 13 hits and they committed one error in the game, while they were led by Meyers, who went 4-4 with two home runs and seven RBIs in the win. Houston started Brown, who allowed four hits and three earned runs over 6.0 innings for the win, while King picked up a hold out of the bullpen. 

Prior to this series, the Astros won two out of three against the Tigers, but lost two out of three against the Royals before that. Houston has won four of their last six games, and they are currently second in the AL West standings. The Houston pitching staff has a 3.35 ERA with a 1.10 WHIP and a .214 opponent batting average, while their offense has scored 128 runs with a .241 batting average and a .312 on-base percentage this season. Isaac Paredes has led Houston with four home runs and 14 RBIs, while Yordan Alvarez has added three home runs, 18 RBIs, and one stolen base this year. The projected starting pitcher for Houston is Lance McCullers Jr., who is making his first appearance of the season. 

Chicago White Sox Betting Preview

The Chicago White Sox are 9-24 this year, and they have split the first two games in this series by scores of 7-3 and 3-8. In their game two loss, the White Sox scored three runs in the first inning, but went scoreless in the final eight innings for the loss. The White Sox recorded six hits in the game, and they were led by Vaughn, who had two RBIs in the loss. Chicago started Martin, who allowed eight hits and three earned runs over 5.0 innings, while Ellard allowed two earned runs in just 0.2 innings for the loss. 

Prior to this series, the White Sox lost two out of three against the Brewers and two out of three against the Athletics. Chicago has lost four of their last six games, and they are currently last in the AL Central standings. The Chicago pitching staff has a 4.14 ERA with a 1.36 WHIP and a .239 opponent batting average, while the offense has scored 119 runs with a .215 batting average and a .294 on-base percentage this season. Luis Robert has led Chicago with five home runs and 14 RBIs, while Andrew Benintendi has added five home runs and 12 RBIs this year. The projected starting pitcher for Chicago is Bryse Wilson, who is 0-1 with a 5.00 ERA and a 1.78 WHIP over 18.0 innings pitched this year. 

Why the White Sox will beat the Astros 

• The Astros have lost each of their last four games as road favorites following a win.
• The White Sox have won each of their last three day games against American League opponents following a loss.
• The Astros have failed to cover the run line in each of their last six day games against American League opponents following a win.
• The White Sox have covered the run line in each of their last four day games against American League opponents following a loss.
• The Astros have lost the first inning in four of their last five road games against AL Central opponents that held a losing record.
• The White Sox have led after 3 innings in four of their last five home games.

Why the Astros will beat the White Sox 

• The White Sox have lost each of their last six games against American League opponents following a home loss.
• The Astros have won four of their last five games after playing the previous day.
• The White Sox have failed to cover the run line in each of their last six games as underdogs against American League opponents following a home loss.
• The Astros have covered the run line in each of their last six Sunday road games against AL Central opponents.

Total Runs Facts

• Each of the Astros’ last six games have gone OVER the total runs line.
• Four of the White Sox’s last five games have gone OVER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the White Sox’s last seven games as underdogs.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Astros’ last four games.

Chicago White Sox Player Prop Facts

• Luis Robert has hit a home run in four of the White Sox’s last eight home games against the Astros.
• Andrew Benintendi has recorded an RBI in each of his last three home appearances against the Astros.
• Miguel Vargas has scored a run in each of the White Sox’s last four home games.
• Andrew Benintendi has recorded at least one Single in each of his last four home appearances after playing the previous day.
• Andrew Benintendi has recorded at least one hit in each of his last seven appearances at Rate Field against AL West opponents that held a winning record.

Houston Astros Player Prop Facts

• Lance McCullers Jr. has recorded seven or more strikeouts in seven of his last eight road appearances against AL opponents that held a losing record.
• Jose Altuve has scored at least one run in each of his last eight Sunday day appearances against AL Central teams that held a losing record.
• Yordan Alvarez has recorded at least one RBI in each of his last seven Sunday appearances against AL Central teams that held a losing record.
• Lance McCullers Jr. has recorded a win in five of his last six appearances with the Astros as favorites against the White Sox.
• Yainer Diaz has hit a home run in two of the Astros’ last three games against the White Sox.
• Jake Meyers has recorded a Double in three of the Astros’ last four day games against AL opponents that held a losing record.
• Mauricio Dubon has recorded at least one hit in 14 of his last 15 road appearances against AL Central opponents that held a losing record.
• Jeremy Pena has recorded at least one Single in 14 of the Astros’ last 15 games as favorites against AL opponents.

Astros vs White Sox Prediction 

Houston dropped the first game in this series on Friday, and they fell down 3-0 early on Saturday, but they were able to rally and get a much-needed win. The Astros are just 6-8 on the road, while the White Sox are 6-11 at home. Chicago is starting Wilson, who is only expected to pitch a few innings, but has some rough numbers on the year. Houston is going with McCullers Jr., who is coming off the IL for his first outing. The Chicago offense is a concern, but I don’t like either pitcher here. Take the over in this game. 

David Racey's Pick: Over 8.5