Astros vs Blue Jays Prediction 9/10/2025 Today’s MLB Picks

In this article we will formulate an Astros vs Blue Jays prediction for this MLB game on Wednesday, September 10th at the Rogers Centre in Toronto, Ontario. Let’s take a look at the prediction for this MLB matchup. 

Houston Astros Betting Preview

The Houston Astros are 78-67 this year after they lost game one by a score of 4-3 on Tuesday night. Houston led 3-0 in the sixth inning, but they blew the lead and ended up losing in the 10th inning. The Astros recorded 11 hits and they committed one error in the game, while they were led by Correa, who went 1-3 with one home run and two RBIs in the loss. Houston started Garcia, who only went 1.2 innings due to injury, while Abreu blew the save and Kimbrel picked up the loss. 

Prior to this series, the Astros lost two out of three against the Rangers and two out of three against the Yankees. Houston has lost four of their last five games and they are currently first in the AL West standings. The Houston pitching staff has a 3.85 ERA with a 1.22 WHIP and a .231 opponent batting average, while their offense has scored 612 runs with a .253 batting average and a .318 on base percentage this season. Jose Altuve has led Houston with 24 home runs and 69 RBIs, while Christian Walker has added 22 home runs and 76 RBIs this year. The projected starting pitcher for Houston is Jason Alexander, who is 4-1 with a 4.68 ERA and a 1.39 WHIP over 59.2 innings pitched this year. 

Toronto Blue Jays Betting Preview

The Toronto Blue Jays are 83-61 this season after they won game one in dramatic fashion by a score of 4-3 on Tuesday night. Toronto scored once in the sixth, twice in the ninth, and once in the 10th to escape with the extra innings win. The Blue Jays recorded seven hits in the game and they were led by Kiner-Falefa, who went 1-2 with two RBIs in the win. Toronto started Bieber, who allowed nine hits and three earned runs over 5.2 innings, while Hoffman picked up the win in relief. 

Prior to this series, the Blue Jays lost two out of three against the Yankees, but did win two out of three against the Reds before that. Toronto has won four of their last six games and they are currently first in the AL East standings. The Toronto pitching staff has a 4.23 ERA with a 1.27 WHIP and a .241 opponent batting average, while their offense has scored 719 runs with a .269 batting average and a .338 on base percentage this season. Vladimir Guerrero Jr. has led Toronto with 23 home runs and 79 RBIs, while George Springer has added 28 home runs and 73 RBIs this year. The projected starting pitcher for Toronto is Jose Berrios, who is 9-5 with a 4.02 ERA and a 1.29 WHIP over 154.2 innings pitched this season. 

Why the Blue Jays will beat the Astros 

The Blue Jays have won seven of their last eight night games against AL West opponents.
The Astros have lost each of their last four games at Rogers Centre against American League opponents that held a winning record.
The Astros have failed to cover the run line in 11 of their last 13 games against American League opponents after going to extra innings.
The Blue Jays have covered the run line in five of their last six games after playing the previous day.
The Blue Jays have led after 5 innings in three of their last four night games against opponents that held a winning record.

Total Runs Facts

Each of the Astros’ last six road games after going to extra innings have gone OVER the total runs line.
Seven of the Blue Jays’ last eight home games against American League opponents have gone OVER the total runs line.
The ‘Inning 1 UNDER 0.5 runs’ market has hit in 10 of the Astros’ last 11 games.
The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Blue Jays’ last five night games against American League opponents.

Toronto Blue Jays Player Prop Facts

George Springer has hit a home run in three of the Blue Jays’ last four games as home favorites against the Astros.
Jose Berrios has recorded five or more strikeouts in 21 of his 24 previous Wednesday appearances in night games.
Bo Bichette has recorded at least one hit in each of his last 15 home appearances against AL opponents.
Jose Berrios has recorded a win in five of his last six home appearances against the Astros.
Bo Bichette has recorded at least one Double in four of his last five appearances with the Blue Jays as favorites against AL West opponents.
Vladimir Guerrero Jr. ranks 4th amongst qualified players for On Base Percentage (.394) this season.

Houston Astros Player Prop Facts

Yordan Alvarez has hit a home run in three of the Astros’ last five road games against the Blue Jays.
Yordan Alvarez has recorded a Double in each of the Astros’ last three games as underdogs against AL East opponents.
Jake Meyers has recorded at least one hit in each of his last 13 appearances against AL opponents.
Jeremy Pena is one of only seven players to hit over .300 and have 45+ RBIs this season.

Matchup/League Facts

The Blue Jays rank 1st in the league for on-base percentage this season (.338).
The Blue Jays rank 1st in the league for strikeouts against this season (966).
The Astros rank T26th in the league for steals this season (72).
The Astros rank 5th in the league for opponent batting average this season (.232).

Astros vs Blue Jays Prediction 

Toronto was able to storm back to tie the game in the ninth inning on Tuesday night and they got a huge win, as they picked up another game on the Yankees. The Blue Jays are 46-24 at home this season, while the Astros are 35-35 on the road. Houston has dropped four of their last five and their lead in the West is down to one game. The Astros are starting Alexander, who has allowed 3, 3, 2, 2, and 0 earned runs in his last five starts. Toronto is going with Berrios, who has allowed two earned runs or fewer in three of his last four. I don’t really trust either starter in this contest, but I think Toronto has all of the momentum right now. Take the Jays here.