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Arizona Diamondbacks vs St. Louis Cardinals Prediction 6/25/2026 Today’s MLB Picks

May 23, 2026; Phoenix, Arizona, USA; Arizona Diamondbacks pitcher Zac Gallen (23) throws a pitch against the Colorado Rockies in the third inning at Chase Field. Mandatory Credit: Anna Carrington-Imagn Images

May 23, 2026; Phoenix, Arizona, USA; Arizona Diamondbacks pitcher Zac Gallen (23) throws a pitch against the Colorado Rockies in the third inning at Chase Field. Mandatory Credit: Anna Carrington-Imagn Images

MATCHUP Arizona Diamondbacks St. Louis Cardinals
Team Records 41-39 42-36
Spread +1.5 -186 -1.5 153
Moneyline +113 -136
Total Over 9 (-105) Under 9 (-114)
Where Busch Stadium, St. Louis, Missouri
When Thursday, June 25, 2026
Time 07:45 PM EDT
TV ESPN Unlmtd
In this article, we will formulate a Diamondbacks vs Cardinals Prediction for this MLB matchup on Thursday, June 25th in the fourth game of this series. Let’s take a look at the prediction for this MLB matchup.

St. Louis Cardinals Preview


The St. Louis Cardinals have a 42-36 record this season and are sitting in the 2nd place of the NL Central. They have a 22-19 home record and are coming off a 4-9 home defeat against the Diamondbacks. They will face the Marlins and the Braves next.

The Cardinals have a .249 batting average this season, .327 OBP and .399 Slugging percentage. St. Louis’s pitching staff has a 4.30 ERA and 1.35 WHIP. Jordan Walker is the team’s best hitter with a .290 batting average, also leading the team in RBI with 58 and adding a team-high 18 home runs.

Michael McGreevy (R) is the projected starting pitcher for the Cardinals, and he has a 3-6 record, 3.35 ERA and 1.15 WHIP.

Arizona Diamondbacks Preview


The Arizona Diamondbacks have a 41-39 record this season and are sitting in the 3rd place of the NL West. They have a 17-22 road record and are coming off a 9-4 road win against the Cardinals. They will face the Rays and the Giants next.

The Diamondbacks have a .239 batting average this season, .310 OBP and .386 Slugging percentage. Arizona’s pitching staff has a 4.29 ERA and 1.30 WHIP. Corbin Carroll is the team’s best hitter with a .279 batting average. Ketel Marte leads the team in RBI with 47, adding a team-high 13 home runs.

Zac Gallen (R) is the projected starting pitcher for the Diamondbacks, and he has a 3-6 record, 6.10 ERA and 1.63 WHIP.

Arizona Diamondbacks @ St. Louis Cardinals Betting Trends: June 25, 2026


Why the St. Louis Cardinals will win


Why the Arizona Diamondbacks will win

Total Runs Facts

St. Louis Cardinals Player Prop Facts

Arizona Diamondbacks Player Prop Facts

Matchup/League Facts

Diamondbacks vs Cardinals Prediction


The Diamondbacks are 5-1 in their last 6 meetings against the Cardinals but are 2-5 in their last 7 visits in Saint Louis.

In this Diamondbacks vs Cardinals Prediction, the Cardinals are coming as -130 home favorites. I am with the Cardinals in this one with Michael McGreevy on the bump, who has been the far better option that the terrible Zac Gallen. McGreevy sits on a 2.25 home ERA, while Gallen has been atrocious with 4+ earned runs in four of his last five starts and has been weaker on the road. The Cardinals have a better offense and are 4th-best against right-handed pitching in the last 10 days. Take the Cardinals in this one.

Nikos Lagouretos's Pick: St. Louis Cardinals ML

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