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Arizona Diamondbacks vs San Francisco Giants Prediction 5/14/25 MLB Picks

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San Francisco Giants (25-18) vs Arizona Diamondbacks (22-21)

Game Info: Wednesday, May 14, 2025 at 3:45 pm (Oracle Park)

The Line: Betting Odds: San Francisco Giants -110 / Arizona Diamondbacks -110 — Over/Under: 8

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The Arizona Diamondbacks and San Francisco Giants meet Wednesday in MLB action at Oracle Park. Here’s an Arizona Diamondbacks vs San Francisco Giants Prediction. This article will include an Arizona Diamondbacks vs San Francisco Giants Pick.

Arizona Diamondbacks Betting Preview

The Arizona Diamondbacks are 22-21 on the year and play the Rockies, Dodgers, and Cardinals next. The Arizona Diamondbacks are batting .250 on the season, have a .331 OBP, and a .439 slugging percentage. The Arizona Diamondbacks pitching staff has a 4.65 ERA and a 1.34 WHIP. Corbin Carroll leads the Arizona Diamondbacks with 51 hits and 31 RBI, while Josh Naylor and Geraldo Perdomo have combined for 90 hits and 57 RBI. 

Eduardo Rodriguez gets the ball for the Arizona Diamondbacks, and he is 1-3 with a 6.86 ERA and 48 strikeouts this season. Rodriguez is 1-1 with a 5.06 ERA and 18 strikeouts in his career against the San Francisco Giants.

San Francisco Giants Betting Preview

The San Francisco Giants are 25-18 on the year and play the Athletics, Royals, and Nationals next. The San Francisco Giants are batting .235 on the season, have a .309 OBP, and a .385 slugging percentage. The San Francisco Giants’ pitching staff has a 3.45 ERA and a 1.23 WHIP. Jung Hoo Lee leads the San Francisco Giants with 47 hits and 27 RBI, while Heliot Ramos and Willy Adames have combined for 83 hits and 40 RBI.

Jordan Hicks gets the ball for the San Francisco Giants, and he is 1-4 with a 5.82 ERA and 40 strikeouts this season. Hicks is 0-0 with a 3.60 ERA and 23 strikeouts in his career against the Arizona Diamondbacks.

Why the San Francisco Giants will win

Why the Arizona Diamondbacks will win

San Francisco Giants Player Prop Facts

Arizona Diamondbacks Player Prop Facts

Arizona Diamondbacks vs San Francisco Giants Prediction

I’m not looking to back either of these teams given the pitching matchup. Rodriguez looks like a shell of himself, allowing 53 hits and 31 earned runs in 40.2 innings. In 19.2 road innings, Rodriguez has a 7.32 ERA and .326 allowed batting average. He’s allowing a .308 batting average on the season. Hicks has allowed 46 hits and 28 earned runs in 43.1 innings. In 20.1 home innings, Hicks has a 5.75 ERA and .286 allowed batting average. No, thank you. These are two capable lineups as well. I expect some fireworks. Give me the over between the Diamondbacks and Giants. 

Randy Chambers's Pick: Over 8

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