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Arizona Diamondbacks vs San Francisco Giants Prediction 5/26/2026 Today’s MLB Picks

May 25, 2026; San Francisco, California, USA; Arizona Diamondbacks players high five after the game against the San Francisco Giants at Oracle Park. Mandatory Credit: Kelley L Cox-Imagn Images

May 25, 2026; San Francisco, California, USA; Arizona Diamondbacks players high five after the game against the San Francisco Giants at Oracle Park. Mandatory Credit: Kelley L Cox-Imagn Images

MATCHUP Arizona Diamondbacks San Francisco Giants
Team Records 29-24 22-32
Spread -1.5 150 +1.5 -182
Moneyline -114 -106
Total Over 8 (-109) Under 8 (-111)
Where Oracle Park, San Francisco, California
When Tuesday, May 26, 2026
Time 09:45 PM EDT
TV MLB.TV
The Arizona Diamondbacks and San Francisco Giants meet Tuesday in MLB action at Oracle Park. Here’s an Arizona Diamondbacks vs San Francisco Giants Prediction. This article will include an Arizona Diamondbacks vs San Francisco Giants Pick.

Arizona Diamondbacks Betting Preview


The Arizona Diamondbacks are 29-24 on the year and play the Mariners and Dodgers next. The Arizona Diamondbacks are batting. 249 on the season, have a .314 OBP, and have a .404 slugging percentage. The Arizona Diamondbacks’ pitching staff has a 4.04 ERA and a 1.24 WHIP. Ildemaro Vargas leads the Arizona Diamondbacks with 55 hits and 32 RBI, while Ketel Marte and Corbin Carroll have combined for 110 hits and 58 RBI.

Eduardo Rodriguez gets the ball for the Arizona Diamondbacks, and he is 4-1 with a 2.24 ERA and 43 strikeouts this season. Rodriguez is 2-1 with a 5.19 ERA and 30 strikeouts in his career against the San Francisco Giants.

San Francisco Giants Betting Preview


The San Francisco Giants are 22-32 on the year and play the Brewers and Rockies next. The San Francisco Giants are batting. 246 on the season, have a .294 OBP, and have a .385 slugging percentage. The San Francisco Giants’ pitching staff has a 4.22 ERA and a 1.34 WHIP. Luis Arraez leads the San Francisco Giants with 64 hits and 18 RBI, while Rafael Devers and Casey Schmitt have combined for 102 hits and 56 RBI.

Tyler Mahle gets the ball for the San Francisco Giants, and he is 1-6 with a 6.10 ERA and 54 strikeouts this season. Mahle is 0-2 with a 3.09 ERA and 46 strikeouts in his career against the Arizona Diamondbacks.

Why the San Francisco Giants will win

Why the Arizona Diamondbacks will win

Total Runs Facts

San Francisco Giants Player Prop Facts

Arizona Diamondbacks Player Prop Facts

Matchup/League Facts

Arizona Diamondbacks vs San Francisco Giants Prediction


The Diamondbacks continue to pile up the wins over the last two weeks, while the Giants look like a team that just doesn’t have enough. Rodriguez looks like he could make his first all-star appearance of his career with a 2.24 ERA and 1.19 WHIP through 60.1 innings. Mahle has been a disaster with a 6.10 ERA and 1.57 WHIP through 51.2 innings. In his last 15.2 innings, Mahle has allowed 23 hits and 15 runs. It’s awful, folks. The price feels like a steal. I’ll gladly side with the Diamondbacks in this spot, as you can argue they should be much steeper favorites.

Randy Chambers's Pick: Arizona Diamondbacks

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