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Arizona Diamondbacks vs San Diego Padres Prediction 9/28/2025 Today’s MLB Picks

Sep 27, 2025; San Diego, California, USA; San Diego Padres second baseman Jake Cronenworth (9) throws over Arizona Diamondbacks catcher Adrian Del Castillo (25) as he turns a double play during the fifth inning at Petco Park. Mandatory Credit: Denis Poroy-Imagn Images

Sep 27, 2025; San Diego, California, USA; San Diego Padres second baseman Jake Cronenworth (9) throws over Arizona Diamondbacks catcher Adrian Del Castillo (25) as he turns a double play during the fifth inning at Petco Park. Mandatory Credit: Denis Poroy-Imagn Images

MATCHUP Arizona Diamondbacks San Diego Padres
Team Records 80-81 89-72
Where Petco Park, San Diego, California
When Sunday, September 28, 2025
Time 03:10 PM EDT
TV MLB.TV
The Arizona Diamondbacks and San Diego Padres meet Sunday in MLB action at Petco Park. Here’s a Arizona Diamondbacks vs San Diego Padres Prediction. This article will include a Arizona Diamondbacks vs San Diego Padres Pick.

Arizona Diamondbacks Betting Preview


The Arizona Diamondbacks are 80-81 on the year after playing the Dodgers. The Arizona Diamondbacks are batting .251 on the season, have a .324 OBP, and a .433 slugging percentage. The Arizona Diamondbacks pitching staff has a 4.45 ERA and a 1.31 WHIP. Geraldo Perdomo leads the Arizona Diamondbacks with 171 hits and 98 RBI while Corbin Carroll and Ketel Marte have combined for 281 hits and 155 RBI.

Brandon Pfaadt gets the ball for the Arizona Diamondbacks, and he is 13-8 with a 5.00 ERA and 142 strikeouts this season. Pfaadt is 3-2 with a 3.23 ERA and 45 strikeouts in his career against the San Diego Padres.

San Diego Padres Betting Preview


The San Diego Padres are 89-72 on the year after playing the Brewers. The San Diego Padres are batting .252 on the season, have a .320 OBP, and a .389 slugging percentage. The San Diego Padres pitching staff has a 3.63 ERA and a 1.21 WHIP. Luis Arraez leads the San Diego Padres with 181 hits and 61 RBI while Manny Machado and Fernando Tatis Jr. have combined for 325 hits and 164 RBI.

JP Sears gets the ball for the San Diego Padres, and he is 8-11 with a 5.12 ERA and 113 strikeouts this season. Sears is 0-1 with a 6.55 ERA and 10 strikeouts in his career against the Arizona Diamondbacks.

Arizona Diamondbacks @ San Diego Padres Betting Trends: September 28, 2025


Why the San Diego Padres will win

Why the Arizona Diamondbacks will win

Total Runs Facts

San Diego Padres Player Prop Facts

Arizona Diamondbacks Player Prop Facts

Arizona Diamondbacks vs San Diego Padres Prediction


The Padres have nothing to play for, as they’re locked into a playoff series with the Cubs. I wouldn’t be surprised if key players sit. Sears has also been awful since coming over from the Athletics, as he’s allowed 24 hits and 13 earned runs in his last 19 innings. However, the Diamondbacks have played depressed ball since getting bounced from the playoff race, and Pfaadt doesn’t inspire confidence with his 5.00 ERA and 1.33 WHIP. In 75.1 road innings, Pfaadt has a 7.29 ERA and .310 allowed batting average. Backups or not for the Padres, I’m siding with the home team.

Randy Chambers's Pick: San Diego Padres

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