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Arizona Diamondbacks vs San Diego Padres Prediction 9/27/2026 Today’s MLB Picks

Aug 22, 2026; Phoenix, Arizona, USA;  Arizona Diamondbacks pitcher Michael Soroka (34) throws against the Cincinnati Reds in the first inning at Chase Field.  Mandatory Credit: Anna Carrington-Imagn Images

Aug 22, 2026; Phoenix, Arizona, USA; Arizona Diamondbacks pitcher Michael Soroka (34) throws against the Cincinnati Reds in the first inning at Chase Field. Mandatory Credit: Anna Carrington-Imagn Images

MATCHUP Arizona Diamondbacks San Diego Padres
Team Records 86-75 90-71
Spread -1.5 134 +1.5 -162
Moneyline -135 +112
Total Over 8 (-107) Under 8 (-112)
Where Petco Park, San Diego, California
When Sunday, September 27, 2026
Time 03:10 PM EDT
TV MLB.TV
In this article, we will formulate a Diamondbacks vs Padres Prediction for this MLB matchup on Sunday, September 27th in the final game of the regular season. Let’s take a look at the prediction for this MLB matchup.

San Diego Padres Preview


The San Diego Padres have a 90-71 record this season and are sitting in the 2nd place of the NL West. They have a 50-30 home record and are coming off a 10-7 home win against the Diamondbacks.

The San Diego Padres have a .244 batting average this season, .319 OBP and .398 Slugging percentage. San Diego’s pitching staff has a 3.99 ERA and 1.30 WHIP. Fernando Tatis Jr. is the team’s best hitter with a .289 batting average. Manny Machado leads the team in RBI with 90, adding a team-high 30 home runs.

Randy Vasquez (R) is the projected starting pitcher for the Padres, and he has a 10-6 record, 4.01 ERA and 1.30 WHIP.

Arizona Diamondbacks Preview


The Arizona Diamondbacks have a 86-75 record this season and are sitting in the 3rd place of the NL West. They have a 41-39 away record and are coming off a 7-10 road loss against the Padres.

The Arizona Diamondbacks have a .246 batting average this season, .318 OBP and .403 Slugging percentage. Arizona’s pitching staff has a 4.14 ERA and 1.28 WHIP. Gabriel Moreno is the team’s best hitter with a .311 batting average. Nolan Arenado leads the team in RBI with 86, adding a team-high 30 home runs.

Michael Soroka (R) is the projected starting pitcher for the Diamondbacks, and he has a 9-5 record, 3.31 ERA and 1.09 WHIP.

Arizona Diamondbacks @ San Diego Padres Betting Trends: September 27, 2026


Why the San Diego Padres will win

Why the Arizona Diamondbacks will win

Total Runs Facts

San Diego Padres Player Prop Facts

Arizona Diamondbacks Player Prop Facts

Matchup/League Facts

Diamondbacks vs Padres Prediction


Both teams are tied 5-5 in their last 10 meetings and the Dbacks have won two of their last three visits in San Diego.

In this Diamondbacks vs Padres Prediction, the Diamondbacks are coming as -125 road favorites. This is a do-or-die game for the Diamondbacks and they are putting Michael Soroka on the bump, who has been excellent this season with a 3.31 ERA and 1.09 WHIP. He will go up against Randy Vasquez, who has worse numbers and a 5.61 xERA and Arizona’s offense has been scorching-hot, averaging 8.4 runs per game with a .317 batting average in their last 5 games. Take the Dbacks to win this one.

Nikos Lagouretos's Pick: Arizona Diamondbacks ML

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