Arizona (46-47) vs San Diego (49-43)
July 10, 2025 at 09:40 PM EDT
The Line: Betting Odds: San Diego +1.5 — Over/Under: +8.5
In this article, we will formulate a Diamondbacks vs Padres prediction for this MLB game on Thursday, July 10, at PETCO Park in San Diego, California. Let’s take a look at the prediction for this MLB matchup.
Arizona Diamondbacks Betting Preview
The Arizona Diamondbacks (46-47, 23-22 Away) are without a win in the last three series, as the Miami Marlins swept them, split with the San Francisco Giants, and lost to the Kansas City Royals. Arizona beat San Diego in two of three games in this series and will be looking to clinch it on Thursday. In Wednesday’s 8-2 victory, Geraldo Perdomo blasted a grand slam off Dylan Cease to lead his offense, while Brandon Pfaadt got the win after allowing two runs on four hits with four strikeouts and no walks across 8.0 innings of work.
This year, the Diamondbacks average 5.11 runs per game (4th in the MLB) on a .251/.328/.445 triple-slash. When it comes to pitching, the Diamondbacks’ staff has a 4.61 ERA (25th) and 1.31 WHIP (20th). Eugenio Suarez leads the Diamondbacks with a .251 batting average, 29 home runs, and 75 RBI this season.
The projected starting pitcher for the Diamondbacks is Eduardo Rodriguez, who is 3-5 in 15 starts this season, with a 5.78 ERA and 1.62 WHIP in 76.1 innings.
San Diego Padres Betting Preview
The San Diego Padres (49-43, 28-17 Home) lost back-to-back series against the Cincinnati Reds and Philadelphia Phillies, but responded with a win over the Texas Rangers. After losing two of three opening games of the current series against Arizona, San Diego now needs a win to earn a split. In last night’s 8-2 defeat, Dylan Cease took the loss after allowing six runs on five hits with eight strikeouts and three walks in 6.0 innings.
This season, the Padres average 4.01 runs per game (24th in the MLB) on a .244/.313/.371 triple-slash. When it comes to pitching, the Padres’ staff has a 3.69 ERA (10th) and 1.23 WHIP (8th). Manny Machado leads the Padres with a .287 batting average, 15 home runs, and 53 RBI this season.
Randy Vasquez will take the mound for the Padres on Thursday. The 26-year-old right-hander has a 3-4 record in 18 starts this year with a 3.79 ERA and 1.36 WHIP in 90.1 innings.
Total Runs Facts
Each of the Padres’ last four night games as underdogs have gone UNDER the total runs line.
Six of the Diamondbacks’ last seven night games after playing the previous day have gone OVER the total runs line.
The ‘Inning 1 UNDER 0.5 runs’ market has hit in six of the Padres’ last seven games against National League opponents.
The ‘Inning 1 OVER 0.5 runs’ market has hit in 14 of the Diamondbacks’ last 17 games as road favorites against NL West opponents.
Matchup/League Facts
The Padres rank 27th in the league for home runs this season (78).
The Padres rank 4th in the league for opponent batting average this season (.230).
The Diamondbacks rank T3rd in the league for doubles this season (162).
The Diamondbacks rank 3rd in the league for RBIs this season (465).
Diamondbacks vs Padres Prediction
The Diamondbacks won six of the previous ten H2H encounters, including four of six meetings this season. I expect a close duel that could go either way, so I’ll avoid betting on the winner. I am going with Under instead, even though four of six H2Hs this year went Over. Eduardo Rodriguez had a disappointing start last time out against the Royals following a very strong June, when he posted a 1.98 ERA. I am backing him to bounce back in this game and get a quality start. Randy Vasquez, on the other hand, allowed more than three runs only once in his previous six starts, and I am backing him to keep the D-backs to two or three runs in the opening five or six innings. Back the Under.