Houston (58-42) vs Arizona (50-51)
July 22, 2025 at 09:40 PM EDT
The Line: Betting Odds: Arizona +115 — Over/Under: +8.5
The Houston Astros and the Arizona Diamondbacks meet Tuesday in MLB action from Chase Field. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Houston Astros vs. Arizona Diamondbacks prediction.
Starting Pitching Matchup
The Houston Astros will send out Framber Valdez for the start here, and Valdez is 10-4 with a 2.75 ERA and 125 strikeouts this season. In his career, Valdez is 1-0 with a 0.90 ERA and 10 strikeouts against the Diamondbacks. Arizona will send out Eduardo Rodriguez for the start here, and Rodriguez is 3-6 with a 5.94 ERA and 90 strikeouts this season. In his last five starts against the Astros, Rodriguez is 0-4 with a 6.48 ERA and 13 strikeouts.
Houston Astros Recap
The Houston Astros come into this game looking to build on their 6-3 win over the Diamondbacks on Monday to sit at 58-42 on the year. After this series, the Astros will head home for a series against the Athletics.
Astros Win Back-To-Back Games
Jose Altuve has 103 hits, including 16 doubles, 17 home runs, and 53 RBIs. Jeremy Pena also has 102 hits with 18 doubles, 11 homers, and 40 RBIs with 15 stolen bases as well. Jake Meyers has 15 doubles as well, and Christian Walker has 13 home runs and 50 RBIs but has also accrued a team-high 107 strikeouts so far this season. Altuve also has 6 stolen bases while Jake Meyers has 14 stolen bases this season. Isaac Paredes also has a team-high 19 home runs with 50 RBIs of his own, and Cam Smith has contributed 7 homers and 42 RBIs.
Why the Houston Astros will win
The Astros have won eight of their last nine night games against National League opponents.
The Diamondbacks have lost each of their last four night games against American League opponents.
The road team has covered the run line in 12 of the Astros’ last 13 games.
The Diamondbacks have failed to cover the run line in four of their last five night games against AL West opponents following a home loss.
Houston Astros Player Prop Facts
Framber Valdez has recorded seven or more strikeouts in four of his last five road appearances.
Jose Altuve has recorded a Double in each of the Astros’ last four games against the Diamondbacks.
Yainer Diaz has hit a home run in each of his last two appearances against NL West opponents.
Christian Walker has recorded at least one hit in each of his last 14 road appearances against NL West opponents.
Framber Valdez has recorded a win in each of his last five road appearances.
Arizona Diamondbacks Recap
The Arizona Diamondbacks come into this game looking to bounce back from their loss at the hands of the Astros on Monday to sit at 50-51 on the year. After this series, the Diamondbacks will head on the road for a series against the Pirates.
Diamondbacks Have Four-Game Win Streak Snapped
Corbin Carroll has 84 hits with 21 home runs, 48 RBIs, 13 triples, and 16 doubles, while Josh Naylor has 98 hits with 19 doubles, 11 home runs, and 58 RBIs as well this season. Eugenio Suarez has also added 35 home runs and 85 RBIs, while Geraldo Perdomo has 72 RBIs. Naylor has also chipped in 11 stolen bases as well up to this point in the year, while Suarez has the unfortunate distinction of leading the Diamondbacks with 105 strikeouts so far this season. Carroll also has 12 stolen bases, and Perdomo has
a team-high 15 stolen bases as well this season.
Why the Arizona Diamondbacks will win
The Astros have lost six of their last seven games as favorites.
The underdogs have won four of the Diamondbacks’ last five games.
The Diamondbacks have covered the run line in each of their last 10 Tuesday games against American League opponents.
The Astros have failed to cover the run line each of their last seven games against teams that held a losing record.
Arizona Diamondbacks Player Prop Facts
Eduardo Rodriguez has recorded five or more strikeouts in each of his last four home appearances against AL opponents.
Eugenio Suarez has hit at least one home run in four of the Diamondbacks’ last five home games against opponents that held a winning record.
Josh Naylor has recorded two or more hits in each of the Diamondbacks’ last six night games against AL opponents that held a winning record.
Eugenio Suarez ranks T2nd in the league in Home Runs (36) this season.
Total Runs Facts
Each of the Diamondbacks’ last four night games as underdogs have gone OVER the total runs line.
Each of the Astros’ last three games as favorites against the Diamondbacks have gone OVER the total runs line.
Houston Astros vs. Arizona Diamondbacks Prediction
I’m leaning towards Houston here. I think that Valdez has been solid as of late, and he can hold down Arizona here. On the other side, Rodriguez has had his issues in his career against the Astros, and I think Houston can get another win to add to Arizona’s frustration here. Give me the Astros in this one.