Arizona Diamondbacks vs Chicago Cubs Prediction 4/20/25 MLB Picks

Chris Ruffolo

12 months ago

Chicago Cubs (14-9) vs Arizona Diamondbacks (12-9)

Game Info: Sunday, April 20, 2025 at 2:20 pm (Wrigley Field)

The Line: Betting Odds: Chicago Cubs -125 / Arizona Diamondbacks +105 — Over/Under: 7

The Arizona Diamondbacks and the Chicago Cubs meet Sunday in MLB action from Wrigley Field. We will look at this from a betting perspective and determine the best bets for this game. Here’s an Arizona Diamondbacks vs. Chicago Cubs prediction.

Starting Pitching Matchup

The Arizona Diamondbacks will send out Merrill Kelly for the start here and Kelly is 3-1 with a 5.57 ERA and 16 strikeouts this season. In his last five starts against the Cubs, Kelly is 2-0 with a 2.67 ERA and 20 strikeouts. Jameson Taillon will get the start for the Cubs here and is 1-1 with a 5.40 ERA and 18 strikeouts this season. In his career, Taillon is 1-2 with a 5.24 ERA and 19 strikeouts.

Arizona Diamondbacks Recap

The Arizona Diamondbacks come into this game looking to salvage something from this series after a 6-2 loss at the hands of the Cubs on Saturday to fall to 12-9 on the year. After this series, the Diamondbacks will head home for a series against the Tampa Bay Rays.

Diamondbacks Trying To Avoid The Sweep

Corbin Carroll has a team-high 30 hits with 7 home runs, 19 RBIs and 7 doubles while Josh Naylor has 25 hits with 6 doubles, 4 home runs and 13 RBIs as well this season. Eugenio Suarez has also added 6 home runs and 15 RBIs while Geraldo Perdomo has a team-high 19 RBIs. Naylor has also chipped in a team-high 4 stolen bases as well up to this point in the year while Suarez has the unfortunate distinction of leading the Diamondbacks with 29 strikeouts so far this season.

Why the Arizona Diamondbacks will win

The Diamondbacks have won seven of their last eight games as underdogs against NL Central opponents following a loss.
The Cubs have lost six of their last seven games as favorites against the Diamondbacks following a home win.
The Diamondbacks have covered the run line in each of their last eight Sunday games as underdogs.
The Cubs have failed to cover the run line in six of their last seven games as favorites against the Diamondbacks following a home win.

Arizona Diamondbacks Player Prop Facts

Merrill Kelly has recorded a win in five of his last six road appearances against opponents that held a winning record.
Ketel Marte has hit a home run in four of his last five road appearances against NL Central opponents that held a winning record.
Ketel Marte has recorded at least one RBI in each of his last nine road appearances against NL Central opponents that held a winning record.
Corbin Carroll has recorded at least one hit in each of the Diamondbacks’ last 12 games.
Corbin Carroll has recorded at least one Single in each of the Diamondbacks’ last six games at Wrigley Field against NL Central opponents that held a winning record.
Corbin Carroll has scored at least one run in 10 of the Diamondbacks’ last 11 games as underdogs against NL opponents.
Merrill Kelly has recorded five or more strikeouts in each of his last seven appearances with the Diamondbacks as road underdogs against NL opponents.
Randal Grichuk has recorded a Double in three of his last four appearances against the Cubs.

Chicago Cubs Recap

The Chicago Cubs come into this game looking to keep the ball rolling after Saturday’s victory to improve to 14-9 on the year. After this series, the Cubs will welcome the Los Angeles Dodgers to town.

Cubs Looking To Break Out The Brooms

Kyle Tucker leads the Cubs with 29 hits including team-highs of 8 doubles, 6 home runs and 23 RBIs while Seiya Suzuki also has 22 hits with a pair of doubles and 6 home runs and 18 RBIs of his own. Miguel Amaya’s added 6 doubles and 12 RBIs and Pete Crow-Armstrong also has contributed 8 doubles as well this season. Dansby Swanson has added 4 home runs and 12 RBIs. While he also has the unfortunate distinction of leading the Cubs with 27 strikeouts so far this season. Crow-Armstrong also has a team-high 7 stolen bases while Nico Hoerner has 6 stolen bases this season. Michael Busch has also chipped in 5 home runs and 15 RBIs this season.

Why the Chicago Cubs will win

The Cubs have won four of their last five games at Wrigley Field.
The Diamondbacks have lost each of their last three games at Wrigley Field.
The home team has covered the run line in each of the Cubs’ last five games.
The Diamondbacks have failed to cover the run line in four of their last five games at Wrigley Field against teams that held a winning record.

Chicago Cubs Player Prop Facts

Seiya Suzuki has hit a home run in each of the Cubs’ last three games against the Diamondbacks.
Seiya Suzuki has recorded at least one RBI in each of the Cubs’ last five home games against opponents that held a winning record.
Kyle Tucker has scored at least one run in each of his last 12 Sunday appearances.
Jameson Taillon has recorded five or more strikeouts in each of his last four appearances with his team as a favorite against NL West opponents.
Nico Hoerner has recorded at least one hit in each of his last 15 Sunday appearances against teams that held a winning record.
Jameson Taillon has recorded a win in seven of his last eight appearances in day games.
Justin Turner has recorded at least one Single in 12 of his last 13 appearances with his team as a home favorite against NL West opponents.
Pete Crow-Armstrong ranks T3rd in the league in Steals (7) this season.

Total Runs Facts

Six of the Cubs’ last seven home games have gone OVER the total runs line.
Fifteen of the Diamondbacks’ last 20 day games against National League opponents have gone OVER the total runs line.