San Francisco Giants vs Minnesota Twins Prediction 5/10/25 MLB Picks

Minnesota Twins Betting Preview

The Minnesota Twins are 19-20 on the year and play the Orioles, Brewers, and Guardians next. The Minnesota Twins are batting .237 on the season, have a .308 OBP, and a .371 slugging percentage. The Minnesota Twins pitching staff has a 3.35 ERA and a 1.18 WHIP. Ty France leads the Minnesota Twins with 39 hits and 21 RBI while Byron Buxton and Carlos Correa have combined for 71 hits and 38 RBI.

Joe Ryan gets the ball for the Minnesota Twins, and he is 2-2 with a 2.93 ERA and 47 strikeouts this season. Ryan is 2-1 with a 3.31 ERA and 18 strikeouts in his career against the San Francisco Giants.

Why the Minnesota Twins will win

• The Twins have won each of their last seven games at Target Field.
• The Giants have lost eight of their last nine road games against AL Central opponents that held a losing record.
• The Twins have covered the run line in each of their last seven games at Target Field.
• The Giants have failed to cover the run line in eight of their last nine road games against AL Central opponents that held a losing record.
• The Giants have trailed after 5 innings in four of their last five games at Target Field.
• The Giants have trailed after 3 innings in four of their last five road games against AL Central opponents that held a losing record.

Why the San Francisco Giants will win

• The Twins have lost six of their last seven games as home favorites against National League opponents following a home win.
• The Giants have won five of their last six games as road underdogs following a loss.
• The Giants have covered the run line in each of their last seven games as underdogs against American League opponents following a loss.
• The Twins have failed to cover the run line in each of their last seven games as home favorites against National League opponents following a win.
• The Twins have trailed after 3 innings in six of their last eight night games against National League opponents that held a winning record.

Minnesota Twins Player Prop Facts

• Ryan Jeffers has hit at least one home run in five of his last nine appearances with the Twins as favorites against NL West opponents.
• Ryan Jeffers has recorded at least one Double in three of his last four appearances in night games against NL teams that held a winning record.
• Willi Castro has recorded an RBI in five of the Twins' last six games as favorites against NL opponents.
• Joe Ryan has recorded a win in each of his three previous appearances with the Twins as home favorites against NL West opponents.
• Byron Buxton has scored at least one run in each of his last six appearances at Target Field.
• Joe Ryan has recorded seven or more strikeouts in each of his last five Saturday appearances at Target Field.
• Carlos Correa has recorded at least one Single in each of his last nine home appearances against the Giants.
• Carlos Correa has recorded at least one hit in each of his nine previous home appearances against the Giants after playing the previous day.

San Francisco Giants Player Prop Facts

• Matt Chapman has recorded at least one RBI in three of the Giants' last four games against opponents that held a losing record.
• Logan Webb has recorded a win in three of his last four appearances with the Giants as underdogs against AL opponents.
• Mike Yastrzemski has recorded at least one Single in seven of his last eight appearances after playing the previous day.
• Logan Webb has recorded six or more strikeouts in each of his last four appearances.
• Jung Hoo Lee has recorded at least one hit in each of his last 10 Saturday appearances.
• Tom Murphy has hit a home run in three of his last four appearances against the Twins.
• Tom Murphy has recorded a Double in each of his last three appearances with his team as an underdog against AL Central opponents.
• Tom Murphy has scored at least one run in each of his last five appearances against the Twins.
• Logan Webb ranks T10th in the league for Wins (4) this season.

San Francisco Giants vs Minnesota Twins Prediction

The Giants have cooled off a bit over the last two weeks and Webb just isn’t the same pitcher he is on the road that he is at home. Even this season, Webb has a 0.44 ERA and .219 allowed batting average in 20.1 home innings, but he has a 4.18 ERA and .271 allowed batting average in 28 road innings. The Twins have won six straight games and are getting production across the board. Ryan has allowed 13 runs in 40 innings this season, and he’s given up eight hits and one run in his last 13 innings. The Twins have to be the play on Saturday night.