Philadelphia Phillies vs Cleveland Guardians Prediction 5/10/25 MLB Picks

Cleveland Guardians (23-15) vs Philadelphia Phillies (22-16)

Game Info: Saturday, May 10, 2025 at 6:10 pm (Progressive Field)

R. Suarez (L) vs T. Bibee (R)

Betting Odds: Cleveland Guardians +105 / Philadelphia Phillies -125 --- Over/Under: 8 Click Here for the Latest Odds

Where to Watch: MLB.TV

In this article, we will formulate a Phillies vs Guardians prediction for this MLB game on Saturday, May 10, at Progressive Field in Cleveland, Ohio. Let’s take a look at the prediction for this MLB matchup.

Philadelphia Phillies Betting Preview

The Philadelphia Phillies (22-16, 9-10 Away) won the previous four series, as they beat the Cubs, Nationals, Diamondbacks, and Rays, but they opened the current series against the Cleveland Guardians with a 6-0 defeat on the road. Philadelphia swept the Tampa Bay Rays, which was their first series sweep since early April, but in Cleveland, Aaron Nola took the loss after allowing four runs on six hits with five strikeouts and two walks in 5.0 innings.

This year, the Phillies average 4.76 runs per game (9th in the MLB) on a .257/.338/.401 triple-slash. When it comes to pitching, the Phillies’ staff has a 3.94 ERA (15th) and 1.28 WHIP (16th). Kyle Schwarber leads the Phillies with a .257 batting average, 12 home runs, and 28 RBI this season.

The projected starting pitcher for the Phillies is Ranger Suarez, who is 0-0 in one start this season, with a 17.18 ERA and 2.45 WHIP in 3.2 innings.

Cleveland Guardians Betting Preview

The Cleveland Guardians (23-15, 12-5 Home) are playing well recently; they won eight of the previous ten games and won the series against the Twins, Blue Jays, and Nationals. In the opening game of the series against the Phillies, the Guardians played excellent defense and secured a 6-0 win. Angel Martinez led the offense with two RBI, while Gavin Williams got the win after allowing no runs on four hits with eight strikeouts and four walks in 5.0 innings.

This year, the Guardians average 4.29 runs per game (16th in the MLB) on a .239/.312/.393 triple-slash. When it comes to pitching, the Guardians’ staff has a 4.19 ERA (19th) and 1.43 WHIP (24th). Kyle Manzardo leads the Guardians with a .221 batting average, nine home runs, and 22 RBI this season.

Tanner Bibee will take the mound for the Guardians on Saturday. The 26-year-old right-hander has a 3-2 record in seven starts this year with a 4.26 ERA and 1.32 WHIP in 38.0 innings.

Total Runs Facts

  • Seven of the Guardians' last eight home games against National League opponents have gone UNDER the total runs line.
  • Five of the Phillies' last six night games after playing the previous day have gone UNDER the total runs line.
  • The 'Inning 1 UNDER 0.5 runs' market has hit in each of the Guardians' last five night games.
  • The 'Inning 1 UNDER 0.5 runs' market has hit in each of the Phillies' last four games as road favorites against AL Central opponents.

Matchup/League Facts

  • The Guardians rank 25th in the league for opponent batting average this season (.260).
  • The Guardians rank 24th in the league for hits this season (297).
  • The Phillies rank T3rd in the league for walks allowed this season (110).
  • The Phillies rank 4th in the league for on-base percentage this season (.338).

Phillies vs Guardians Prediction

The Guardians won seven of the previous ten H2H encounters, including three of the last four. Ranger Suarez was dismantled in his first start of the season as he allowed seven runs against Arizona, and although I don't think he will experience another meltdown here, I do believe the Guardians will score 3+ runs off him in the first five innings. Tanner Bibee, on the other hand, is not the pitcher I have confidence in; he allowed multiple runs in five of his last six starts. Eight of Cleveland's last ten games went Over, and I am backing the Over in this one as well.

The pick in this article is the opinion of the writer, not a PickDawgz site consensus.

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