Baltimore Orioles vs Los Angeles Angels Prediction 5/10/25 MLB Picks
Los Angeles Angels (15-22) vs Baltimore Orioles (14-23)
Game Info: Saturday, May 10, 2025 at 9:38 pm (Angel Stadium)
K. Gibson (R) vs J. Kochanowicz (R)
Betting Odds: Los Angeles Angels +124 / Baltimore Orioles -148 --- Over/Under: 9.5 Click Here for the Latest Odds
Where to Watch: MLB.TV
The Baltimore Orioles and the Los Angeles Angels meet Saturday in MLB action from Angel Stadium. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Baltimore Orioles vs. Los Angeles Angels prediction.
Starting Pitching Matchup
Kyle Gibson will get the start for the Orioles here and is 0-1 with a 14.09 ERA and 5 strikeouts this season. In his last five starts against the Angels, Gibson is 2-2 with an 8.39 ERA and 18 strikeouts. Jack Kochanowicz will get the start for the Angels here and is 1-5 with a 5.79 ERA and 20 strikeouts this season. This will be Kochanowicz’s first career start against the Orioles.
Baltimore Orioles Recap
The Baltimore Orioles come into this game looking to build on their 4-1 win over the Angels from Friday’s series opener to improve to 14-23 on the year. After this series, the Orioles will have a rematch series against the Minnesota Twins at home.
Orioles Snap Five-Game Losing Streak
Cedric Mullins has 28 hits so far this season as well as 5 doubles, 7 home runs and 21 RBIs with 5 stolen bases and a .237 batting average while Adley Rutschman has 25 hits with 4 doubles, 4 homers and 10 RBIs. Ryan Mountcastle has 24 hits with 7 doubles and Tyler O’Neill has 14 hits with 3 doubles, a triple and 2 homers with 10 RBIs. Jordan Westburg’s added 4 home runs and Gunnar Henderson has a team-high 33 strikeouts as well this season. Ryan O’Hearn’s also chipped in 29 hits with 4 doubles and 7 home runs with 14 RBIs and Heston Kjerstad’s added 3 homers and 13 RBIs.
Why the Baltimore Orioles will win
- The Orioles have won seven of their last eight night games against AL West opponents that held a losing record.
- The Angels have lost eight of their last nine night games against the Orioles at Angel Stadium of Anaheim following a loss.
- The Orioles have covered the run line each of their last five games against AL West opponents that held a losing record.
- The Angels have failed to cover the run line in 13 of their last 15 night games against the Orioles at Angel Stadium of Anaheim following a loss.
Baltimore Orioles Player Prop Facts
- Ramon Laureano has recorded a Double in three of his last four appearances against opponents that held a losing record.
- Gunnar Henderson has hit a home run in each of the Orioles' last three games against the Angels.
- Kyle Gibson has recorded a win in four of his last five appearances with his team as a favorite against AL West opponents .
- Jorge Mateo has scored at least one run in each of his last five appearances at Angel Stadium of Anaheim against AL West opponents that held a losing record.
- Kyle Gibson has recorded five or more strikeouts in 12 of his last 13 road appearances.
- Ramon Laureano has recorded at least one hit in 17 of his last 18 appearances in night games against teams that held a losing record.
- Tyler O'Neill has recorded a Single in each of his last six road appearances against AL West opponents that held a losing record.
- Gary Sanchez has recorded at least one RBI in each of his last four appearances with his team as a favorite against AL opponents.
Los Angeles Angels Recap
The Los Angeles Angels will try to rebound after falling flat in Friday’s series opener, dropping to 15-22 on the year as a result. After this series, the Angels will head on the road for an interleague series against the San Diego Padres.
Angels Drop Back-To-Back Games
Logan O’Hoppe has 31 hits including 9 home runs and 17 RBIs while Nolan Schanuel has 31 hits with 6 doubles, a triple, 2 home runs and 9 RBIs. Luis Rengifo has 5 doubles with his 25 hits and Taylor Ward also has 25 hits as well while Mike Trout’s added 9 home runs and 18 RBIs so far this season. Jorge Soler also has 8 doubles, 6 home runs and 16 RBIs, but also has the unfortunate distinction of leading the Angels with 41 strikeouts so far this season. Kyren Paris has also chipped in 21 hits with a triple, 6 home runs and 11 RBIs in addition to 5 stolen bases.
Why the Los Angeles Angels will win
- The Orioles have lost each of their last six games following a road win.
- The Angels have won each of their last three Saturday night games as underdogs against American League opponents.
- The Orioles have failed to cover the run line in six of their last seven games as road favorites.
- The Angels have covered the run line in each of their last five Saturday night games.
Los Angeles Angels Player Prop Facts
- Taylor Ward has recorded at least one RBI in five of the Angels' last six games against AL East opponents.
- Yoan Moncada has scored a run in eight of his last nine home appearances against opponents that held a losing record.
- Mike Trout has hit a home run in each of his last two home appearances against the Orioles.
- Mike Trout has recorded at least one hit in each of his last 13 home appearances against AL East opponents that held a losing record.
- Tim Anderson has recorded at least one Single in 10 of his last 11 appearances at Angel Stadium of Anaheim against opponents that held a losing record.
Total Runs Facts
- Nine of the Orioles' last 10 games as road favorites have gone UNDER the total runs line.
- Five of the Angels' last six games against AL East opponents have gone OVER the total runs line.
Baltimore Orioles vs. Los Angeles Angels Prediction
I’m on the over in this game. I get the case to be made for or against either side, but I can’t back either starting pitcher in this game, as both have been batting practice for opposing teams so far this season. I think the Angels could get a couple of homers against Kyle Gibson, and as much as Baltimore’s had their issues this season, I still think this is a really talented lineup for the Orioles at the end of the day so give me the over in this one.
Chris’s Pick Over 9.5
AUTHOR: Chris Ruffolo

Follow Chris Ruffolo on Twitter @ruffthepickdawg