White Sox vs Royals Prediction 5/6/25 MLB Picks

Kansas City Royals Betting Preview

The Kansas City Royals are 20-16 this year after they shut out the White Sox in game one on Monday night. Kansas City scored once in the fourth, once in the fifth, and once in the eighth for the win. The Royals recorded seven hits in the game, and they were led by Waters, Garcia, and Witt, who all had one RBI in the win. KC started Ragans, who allowed three hits over 5.0 innings for the win, while Estevez picked up the save. 

Prior to this series, the Royals won two out of three against the Orioles and swept the Rays in three games. Kansas City has won six of its last seven games, and they are currently third in the AL Central standings. The Kansas City pitching staff has a 3.07 ERA with a 1.19 WHIP and a .228 opponent batting average, while the offense has scored 123 runs with a .237 batting average and a .298 on-base percentage this season. Vinnie Pasquantino has led KC with six home runs and 22 RBIs, while Bobby Witt has added four home runs and 18 RBIs this year. The projected starting pitcher for Kansas City is Seth Lugo, who is 3-3 with a 3.07 ERA and a 1.05 WHIP over 44.0 innings pitched this year. 

Why the Royals will beat the White Sox 

• The White Sox have lost each of their last 11 night games against AL Central opponents that held a winning record.
• The Royals have won 16 of their last 17 home games against AL Central opponents that held a losing record.
• The White Sox have failed to cover the run line in each of their last seven night games following a loss.
• The favorites have covered the run line in each of the last six games between the White Sox and Royals at Kauffman Stadium.
• The Royals have led after 5 innings in six of their last seven night games.

Why the White Sox will beat the Royals

• The underdogs have won five of the Royals' last seven games.
• The Royals have lost four of their last five Tuesday games as home favorites against American League opponents.
• The Royals have failed to cover the run line in each of their last 10 Tuesday night home games.
• The White Sox have covered the run line in four of their last five games as road underdogs.

Total Runs Facts

• Each of the Royals' last seven night games against American League opponents have gone UNDER the total runs line.
• Five of the White Sox's last six night games as underdogs have gone OVER the total runs line.
• The 'Inning 1 UNDER 0.5 runs' market has hit in each of the White Sox's last four games as road underdogs against AL Central opponents.
• The 'Inning 1 UNDER 0.5 runs' market has hit in each of the Royals' last four games.

White Sox vs Royals Prediction 

Kansas City was able to stay red hot with a shutout win on Monday night, and they continue to gain ground in the AL Central standings. The Royals have had some issues at the plate, but their pitching staff has been very good. Chicago has played better over the last week or so, but they are just 3-14 on the road this season. The White Sox will start Burke, who has allowed one earned run or fewer in two of his last three starts. The Royals are going with Lugo, who has allowed two earned runs or fewer in two straight. Take the under here.