Red Sox vs Guardians Prediction 4/27/25 MLB Picks

Cleveland Guardians Betting Preview

The Cleveland Guardians are 15-11 this season after they won one game and lost one game on Saturday. In their 5-4 win, Cleveland trailed 3-0 after the top of the first inning, but they scored the next four runs and added one in the sixth for the win. The Guardians recorded 10 hits in the game, and they were led by Ramirez and Kwan, who both went 2-4 with one RBI in the win. Cleveland started Lively, who allowed six hits and four earned runs over 5.0 innings, while Herrin got the win and Smith picked up the save. 

Prior to this series, the Guardians won two out of three against the Yankees and swept the Pirates in three games. Cleveland has won six of their last eight games, and they are currently second in the AL Central standings. The Cleveland pitching staff has a 4.07 ERA with a 1.39 WHIP and a .251 opponent batting average, while the offense has scored 104 runs with a .237 batting average and a .307 on-base percentage this season. Kyle Manzardo has led Cleveland with seven home runs and 18 RBIs, while Steven Kwan has added four home runs and 15 RBIs this year. The projected starting pitcher for Cleveland is Logan Allen, who is 1-1 with a 2.11 ERA and a 1.31 WHIP over 21.1 innings pitched this season. 

Why the Guardians will beat the Red Sox 

• The Guardians have won each of their last eight games as home favorites against American League opponents.
• The Red Sox have lost six of their last seven games against the Guardians following a win.
• The Red Sox have failed to cover the run line each of their last four day games against teams that held a winning record.
• The Guardians have covered the run line in five of their last six day games following a home loss.

Total Runs Facts

• Four of the Red Sox's last five games have gone OVER the total runs line.
• Each of the last three games between the Red Sox and Guardians have gone OVER the total runs line.
• The 'Inning 1 OVER 0.5 runs' market has hit in each of the Red Sox's last seven games against American League opponents.
• The 'Inning 1 OVER 0.5 runs' market has hit in each of the Guardians' last four home games.

Cleveland Guardians Player Prop Facts

• Jose Ramirez has recorded at least one RBI in four of the Guardians' last five games as home favorites against the Red Sox.
• Steven Kwan has recorded at least one Single in each of the Guardians' last 10 games against opponents that held a winning record.
• Steven Kwan has recorded at least one hit in each of the Guardians' last 10 games against opponents that held a winning record.
• Will Brennan has recorded at least one Double in each of his last three appearances with the Guardians as favorites.
• Lane Thomas has scored a run in each of his last four home appearances against the Red Sox.
• Will Brennan has hit a home run in two of his last three appearances in day games against AL East teams that held a winning record.

Boston Red Sox Player Prop Facts

• Alex Bregman has hit at least one home run in two of his last three appearances with the Red Sox as underdogs against AL opponents.
• Rafael Devers has scored at least one run in each of his last five appearances at Progressive Field against opponents that held a winning record.
• Alex Bregman has recorded at least one Single in 12 of his last 13 appearances in day games against AL Central teams that held a winning record.
• Alex Bregman has recorded at least one hit in each of his last 11 road appearances against AL Central opponents that held a winning record.
• Connor Wong has recorded an RBI in each of his last four appearances against AL Central opponents.

Red Sox vs Guardians Prediction 

Both of these teams were able to pick up a win in the doubleheader on Saturday, so they will be looking for the series win here. Cleveland is 8-3 at home this year, while Boston is 7-8 on the road. The Red Sox have lost three of their last four games, and they will be facing Logan Allen, who has allowed a total of one earned run in his last three starts. Cleveland will be going against Brayan Bello, who was fine in his first outing, but I need to see him lower the walks before I back him. Take Cleveland here.