Yankees vs Guardians Prediction 4/21/25 MLB Picks

Cleveland Guardians Betting Preview

The Cleveland Guardians are 12-9 this year after they swept the Pirates in three games by scores of 10-7, 3-0, and 5-4. In their win on Sunday, Cleveland blew a 4-1 lead in the ninth, but ended up escaping with the win in the 10th. The Guardians recorded eight hits and they committed one error in the game, while they were led by Manzardo, who went 2-4 with one home run and three RBIs in the win. Cleveland started Allen, who allowed five hits and one earned run over 5.2 innings, while Clase allowed four hits and three earned runs in the blown save. 

Prior to that series, the Guardians lost two out of three against the Orioles, but did win two out of three against the Royals before that. Cleveland has won four of their last six games, and they are currently second in the AL Central standings. The Cleveland pitching staff has a 3.98 ERA with a 1.35 WHIP and a .250 opponent batting average, while the offense has scored 86 runs with a .238 batting average and a .310 on-base percentage this season. Kyle Manzardo has led Cleveland with six home runs and 16 RBIs, while Steven Kwan has added four home runs and 14 RBIs this year. The projected starting pitcher for Cleveland is Gavin Williams, who is 1-1 with a 4.58 ERA and a 1.32 WHIP over 19.2 innings pitched this season. 

Why the Yankees will beat the Guardians 

• The Yankees have won each of their last seven night games against American League opponents.
• The Guardians have lost each of their last six night games against AL East opponents following a win.
• The favorites have covered the run line in each of the last seven games between the Yankees and Guardians.
• The Guardians have failed to cover the run line in each of their last six night games against AL East opponents following a win.
• The Guardians have trailed after 5 innings in three of their last four games against American League opponents.

Total Runs Facts

• Each of the Yankees' last five games as favorites have gone UNDER the total runs line.
• Four of the Guardians' last five night games after playing the previous day have gone OVER the total runs line.
• The 'Inning 1 UNDER 0.5 runs' market has hit in seven of the Guardians' last eight games as underdogs against American League opponents.
• The 'Inning 1 UNDER 0.5 runs' market has hit in six of the Yankees' last seven games against AL Central opponents.

Cleveland Guardians Player Prop Facts

• Jose Ramirez has recorded a Double in three of the Guardians' last four home games against AL East opponents.
• Steven Kwan has scored at least one run in five of the Guardians' last six games as home underdogs against AL East opponents.
• Nolan Jones has hit a home run in two of his three previous appearances with his team as a home underdog against the Yankees.
• Steven Kwan has recorded at least one hit in each of the Guardians' last 10 games as home underdogs against the Yankees.
• Carlos Santana has recorded at least one RBI in four of his last five appearances against AL East opponents that held a winning record.
• Steven Kwan has recorded at least one Single in each of his last seven appearances with the Guardians as home underdogs against AL opponents.

New York Yankees Player Prop Facts

• Giancarlo Stanton has hit a home run in five of the Yankees' last six games against the Guardians.
• Paul Goldschmidt has recorded at least one hit in each of his last 10 road appearances against opponents that held a winning record.
• Giancarlo Stanton has recorded at least one RBI in each of his last nine road appearances against AL Central opponents that held a winning record.
• Paul Goldschmidt has recorded at least one Single in each of the Yankees' last seven games as road favorites.
• Aaron Judge has scored at least one run in seven of the Yankees' last eight games as favorites against the Guardians.

Yankees vs Guardians Prediction 

Both of these teams are coming off of nice series wins over the weekend and have plenty of momentum, but Cleveland will be at home. The Guardians are 5-1 at home this year, while the Yankees are 6-4 on the road. New York has been the much better offensive team to start the season, and their pitching staff has been very good over the last five games. I think the pitching matchup is pretty even between Schmidt and Williams, so I will gladly take the Yankees and their explosive lineup at a good price. Take the Yankees here.