San Diego Padres vs Houston Astros Prediction 4/20/25 MLB Picks

Houston Astros (10-10) vs San Diego Padres (15-6)

Game Info: Sunday, April 20, 2025 at 7:00 pm (Daikin Park)

D. Cease (R) vs F. Valdez (L)

Betting Odds: Houston Astros -122 / San Diego Padres +102 --- Over/Under: 7.5 Click Here for the Latest Odds

Where to Watch: ESPN

In this article, we will formulate a Padres vs Astros prediction for this MLB game on Sunday, April 20, at Daikin Park in Houston, Texas. Let’s take a look at the prediction for this MLB matchup.

San Diego Padres Betting Preview

The San Diego Padres (15-6, 3-5 Away) were on a five-game winning streak after sweeping the Rockies without allowing a single run in three games, and after winning the series against the Cubs. However, the Padres lost the opening two games of the current series against the Astros. Michael King pitched for 5.2 innings in a no-decision, allowing two runs on four hits with seven strikeouts and two walks.

This year, the Padres average 4.48 runs per game (13th in the MLB) on a .275/.344/.419 triple-slash. When it comes to pitching, the Padres’ staff has a 2.77 ERA (2nd) and 1.10 WHIP (3rd). Fernando Tatis Jr. leads the Padres with a .315 batting average, seven home runs, and 15 RBI this season.

Dylan Cease will take the mound for the Padres on Sunday. The 29-year-old right-hander has a 1-1 record in four starts this year with a 6.64 ERA and 1.52 WHIP in 20.1 innings.

Houston Astros Betting Preview

The Houston Astros (10-10, 6-5 Home) lost the previous series to the St. Louis Cardinals by losing two out of three games, but responded with wins in the opening two games of the current series against the Padres. In the latest 3-2 victory, Christian Walker led the offense with two RBI, while Hayden Wesneski pitched for 5.0 innings in a no-decision, allowing two runs on six hits with four strikeouts and one walk. Tayler Scott was credited with the win.

This season, the Astros average 3.75 runs per game (23rd in the MLB) on a .223/.303/.334 slash line. Regarding pitching, the Astros’ staff has a 3.66 ERA (9th) and 1.13 WHIP (5th). Isaac Paredes leads the Astros with a .240 batting average, three home runs, and 11 RBI this season.

The projected starting pitcher for the Astros is Framber Valdez, who is 1-2 in four starts this season, with a 4.91 ERA and 1.27 WHIP in 22.0 innings.

Total Runs Facts

  • Seven of the Astros' last eight games as favorites against NL West opponents have gone OVER the total runs line.
  • Each of the Padres' last four games as underdogs against the Astros have gone OVER the total runs line.
  • The 'Inning 1 UNDER 0.5 runs' market has hit in 16 of the Astros' last 17 home games against National League opponents.
  • The 'Inning 1 UNDER 0.5 runs' market has hit in each of the Padres' last four games at Daikin Park.

Matchup/League Facts

  • The Astros rank 27th in the league for slugging percentage this season (.334).
  • The Astros rank 4th in the league for hits allowed this season (142).
  • The Padres rank 1st in the league for hits allowed this season (136).
  • The Padres rank T29th in the league for triples this season (0).

Padres vs Astros Prediction

The teams have traded wins in the past few seasons, as each recorded five in the last ten H2H encounters. Even though only one of the last five H2Hs produced more than seven runs, I am going with Over in this one because of the pitching matchup. Cease did allow just .146 BA in 96 at-bats against the Astros, but he's not having a good season so far, and I think he will struggle on Sunday. The same can be said about Framber Valdez, who is far from being impressive thus far. The Padres are hitting a .246 BA against southpaws this season, and I am backing them to score 3+ runs off Framber. I am going with Over. 

The pick in this article is the opinion of the writer, not a PickDawgz site consensus.

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