Chicago White Sox vs Boston Red Sox Prediction 4/19/25 MLB Picks

Boston Red Sox Betting Preview

The Boston Red Sox are 11-10 on the year and play the Mariners, Guardians, and Blue Jays next. The Boston Red Sox are batting .250 on the season, have a .323 OBP, and a .400 slugging percentage. The Boston Red Sox pitching staff has a 4.06 ERA and a 1.30 WHIP. Trevor Story leads the Boston Red Sox with 26 hits and 14 RBI while Alex Bregman and Jarren Duran have combined for 45 hits and 26 RBI.

Garrett Crochet gets the ball for the Boston Red Sox, and he is 2-1 with a 1.38 ERA and 28 strikeouts this season. This will be Crochet’s second career game against the Chicago White Sox.

Why the Boston Red Sox will win

• The White Sox have lost each of their last seven road games against American League opponents.
• The Red Sox have won four of their last five games against American League opponents.
• The White Sox have failed to cover the run line in each of their last five games as underdogs.
• The Red Sox have covered the run line in four of their last five games against American League opponents.
• The White Sox have trailed after 3 innings in four of their last five games against AL East opponents that held a winning record.
• The White Sox have trailed after 5 innings in four of their last five games against AL East opponents that held a winning record.

Why the Chicago White Sox will win

• The Red Sox have lost four of their last five games as home favorites against the White Sox following a home win.
• The White Sox have won each of their last five day games against the Red Sox at Fenway Park following a road loss.
• The Red Sox have failed to cover the run line in each of their last five day games against the White Sox at Fenway Park following a win.
• The White Sox have covered the run line in five of their last six day games against the Red Sox at Fenway Park following a loss.

Chicago White Sox vs Boston Red Sox Prediction

Another White Sox game. Folks, you know what to do. The White Sox lost a combined 222 games in the last two seasons and they’ve lost 15 of their first 19 games this season. There’s nothing left to talk about. The White Sox are on a historically bad run and they have no betting value. I’ve been fading the White Sox over the last two years and that hasn’t stopped yet. Of course, the price is ridiculous, but give me the Red Sox and I’ll lay the RL to shave down the price as much as possible.