Arizona Diamondbacks vs Chicago Cubs Prediction 4/19/25 MLB Picks
Chicago Cubs (13-9) vs Arizona Diamondbacks (12-8)
Game Info: Saturday, April 19, 2025 at 2:20 pm (Wrigley Field)
Z. Gallen (R) vs B. Brown (R)
Betting Odds: Chicago Cubs -105 / Arizona Diamondbacks -115 --- Over/Under: 0.0001 Click Here for the Latest Odds
Where to Watch: MLB.TV
The Arizona Diamondbacks and Chicago Cubs meet Saturday in MLB action at Wrigley Field. Here’s a Arizona Diamondbacks vs Chicago Cubs Prediction. This article will include a Arizona Diamondbacks vs Chicago Cubs Pick.
Arizona Diamondbacks Betting Preview
The Arizona Diamondbacks are 12-8 on the year and play the Rays, Braves, and Mets next. The Arizona Diamondbacks are batting .260 on the season, have a .350 OBP, and a .460 slugging percentage. The Arizona Diamondbacks pitching staff has a 4.55 ERA and a 1.26 WHIP. Corbin Carroll leads the Arizona Diamondbacks with 27 hits and 18 RBI, while Josh Naylor and Geraldo Perdomo have combined for 47 hits and 32 RBI.
Zac Gallen gets the ball for the Arizona Diamondbacks, and he is 1-2 with a 4.64 ERA and 24 strikeouts this season. Gallen is 3-2 with a 3.26 ERA and 42 strikeouts in his career against the Chicago Cubs.
Chicago Cubs Betting Preview
The Chicago Cubs are 13-9 on the year and play the Dodgers, Phillies, and Pirates next. The Chicago Cubs are batting .265 on the season, have a .347 OBP, and a .458 slugging percentage. The Chicago Cubs pitching staff has a 4.45 ERA and a 1.41 WHIP. Kyle Tucker leads the Chicago Cubs with 28 hits and 21 RBI while Ian Happ and Nico Hoerner have combined for 47 hits and 23 RBI.
Ben Brown gets the ball for the Chicago Cubs, and he is 2-1 with a 5.09 ERA and 20 strikeouts this season. This will be Brown’s second career game against the Arizona Diamondbacks.
Why the Chicago Cubs will win
- The underdogs have won four of the last five games between the Diamondbacks and Cubs.
- The Diamondbacks have lost four of their last five games as road favorites against NL Central opponents following a road loss.
- The home team has covered the run line in each of the Cubs' last four games.
- The Diamondbacks have failed to cover the run line in four of their last five games as favorites against NL Central opponents.
- The Diamondbacks have trailed after 5 innings in seven of their last eight games against NL Central opponents.
- The Cubs have led after 3 innings in each of their last three home games against National League opponents.
Why the Arizona Diamondbacks will win
- The Diamondbacks have won each of their last six games against the Cubs following a loss.
- The Cubs have lost each of their last four home games against the Diamondbacks following a win.
- The Cubs have failed to cover the run line in each of their last four home games against the Diamondbacks following a win.
- The Diamondbacks have covered the run line in each of their last four games against the Cubs at Wrigley Field following a loss.
Matchup/League Facts
- The Cubs rank T1st in the league for triples this season (6).
- The Cubs rank 1st in the league for RBIs this season (134).
- The Diamondbacks rank 2nd in the league for runs scored this season (115).
- The Diamondbacks rank 2nd in the league for RBIs this season (113).
Arizona Diamondbacks vs Chicago Cubs Prediction
The Cubs continue to hit the ball well and are worth a look as long as they keep playing at this level. I’m still siding with the Diamondbacks and the cheap price because Gallen is on the mound. Gallen isn’t off to a great start through 21.1 innings, as he’s allowed 19 hits and 11 runs while walking 11, but we know he’s one of the best pitchers in baseball regardless. You’re not going to get Gallen at these prices often and I love my aces at cheap prices. I’ll side the the Diamondbacks on Saturday afternoon.
Randy’s Pick Arizona Diamondbacks -115
AUTHOR: Randy Chambers

Follow Randy Chambers on Twitter @WizardOf0dds