Chicago White Sox vs Boston Red Sox Prediction 4/18/25 MLB Picks
Boston Red Sox (10-10) vs Chicago White Sox (4-14)
Game Info: Friday, April 18, 2025 at 7:10 pm (Fenway Park)
(L) vs (L)
Betting Odds: Boston Red Sox -218 / Chicago White Sox +180 --- Over/Under: 9 Click Here for the Latest Odds
Where to Watch: MLB.TV
The Chicago White Sox and Boston Red Sox meet Friday in MLB action at Fenway Park. Here’s a Chicago White Sox vs Boston Red Sox Prediction. This article will include a Chicago White Sox vs Boston Red Sox Pick.
Chicago White Sox Betting Preview
The Chicago White Sox are 4-14 on the year and play the Twins, Athletics, and Brewers next. The Chicago White Sox are batting .196 on the season, have a .270 OBP, and a .296 slugging percentage. The Chicago White Sox pitching staff has a 4.26 ERA and a 1.32 WHIP. Lenyn Sosa leads the Chicago White Sox with 16 hits and 5 RBI, while Brooks Baldwin and Miguel Vargas have combined for 22 hits and 14 RBI.
Martin Perez gets the ball for the Chicago White Sox, and he is 1-0 with a 1.59 ERA and 18 strikeouts this season. Perez is 5-3 with a 4.55 ERA and 43 strikeouts in his career against the Boston Red Sox.
Boston Red Sox Betting Preview
The Boston Red Sox are 10-10 on the year and play the Mariners, Guardians, and Blue Jays next. The Boston Red Sox are batting .247 on the season, have a .320 OBP, and a .382 slugging percentage. The Boston Red Sox pitching staff has a 4.16 ERA and a 1.33 WHIP. Alex Bregman leads the Boston Red Sox with 25 hits and 16 RBI while Trevor Story and Jarren Duran have combined for 42 hits and 18 RBI.
Hunter Dobbins gets the ball for the Boston Red Sox, and he is 1-0 with a 3.60 ERA and 5 strikeouts this season. This will be Dobbins’ first career game against the Chicago White Sox.
Why the Boston Red Sox will win
- The White Sox have lost each of their last six road games against American League opponents.
- The Red Sox have won four of their last five games at Fenway Park following a win.
- The White Sox have failed to cover the run line in each of their last five games against American League opponents following a home loss.
- The Red Sox have covered the run line in three of their last four games.
- The White Sox have trailed after 5 innings in each of their last three road night games.
Why the Chicago White Sox will win
- The Red Sox have lost four of their last five games as home favorites against American League opponents following a win.
- The White Sox have won three of their last four games as underdogs against the Red Sox.
- The Red Sox have failed to cover the run line in each of their last four games at Fenway Park.
- The underdogs have covered the run line in five of the Red Sox's last six games at Fenway Park.
Matchup/League Facts
- The Red Sox rank T3rd in the league for hits this season (171).
- The Red Sox rank T3rd in the league for steals this season (25).
- The White Sox rank 30th in the league for slugging percentage this season (.296).
- The White Sox rank 30th in the league for on-base percentage this season (.270).
Chicago White Sox vs Boston Red Sox Prediction
It’s hard to get behind Dobbins and his limited sample size, but we’re going to continue to fade the White Sox. I don’t care about a pitching matchup when the White Sox lost 121 games last season and have won just four of 18 games this season. The White Sox are a joke of a franchise and until they start cashing some tickets, we blindly fade them with confidence. There’s nothing left to say here. You see the White Sox, you bet against the White Sox. It’s simple, folks. Of course, I lay the RL to shave down the juice.
Randy’s Pick Boston Red Sox -1.5
AUTHOR: Randy Chambers

Follow Randy Chambers on Twitter @WizardOf0dds