Cleveland Guardians vs Baltimore Orioles Prediction 4/17/25 MLB Picks

Baltimore Orioles (7-10) vs Cleveland Guardians (9-8)

Game Info: Thursday, April 17, 2025 at 6:35 pm (Oriole Park at Camden Yards)

T. Bibee (R) vs T. Sugano (R)

Betting Odds: Baltimore Orioles +100 / Cleveland Guardians -120 --- Over/Under: 9 Click Here for the Latest Odds

Where to Watch: MLB.TV

In this article, we will formulate a Guardians vs Orioles prediction for this MLB game on Thursday, April 17, at Oriole Park at Camden Yards in Baltimore, Maryland. Let’s take a look at the prediction for this MLB matchup.

Cleveland Guardians Betting Preview

The Cleveland Guardians (9-8, 4-7 Away) won six of the previous eight games. They swept the Chicago White Sox and beat the Royals in two of three games, and opened the current series against the Orioles with a 6-3 win, but Baltimore responded with a 9-1 win. Gavin Williams took the loss after allowing five runs on four hits with four strikeouts and four walks in 6.2 innings.

This year, the Guardians average 3.88 runs per game (22nd in the MLB) on a .229/.308/.379 triple-slash. When it comes to pitching, the Guardians’ staff has a 3.92 ERA (14th) and 1.34 WHIP (23rd). Steven Kwan leads the Guardians with a .313 batting average, three home runs, and 11 RBI this season.

Tanner Bibee will take the mound for the Guardians on Thursday. The 26-year-old right-hander has a 1-1 record in three starts this season with a 4.40 ERA and 1.47 WHIP in 14.01 innings.

Baltimore Orioles Betting Preview

The Baltimore Orioles (7-10, 3-4 Home) lost the series to the Red Sox, Royals, and Diamondbacks, while they split the series with the Blue Jays. They opened the current three-game series with a 6-3 loss but responded with a comfortable 9-1 victory over the Guardians. Jackson Holliday led the offense with four RBI, while Dean Kremer got the win after allowing one run on four hits with two strikeouts and one walk in  5.1 innings.

This season, the Orioles average 4.59 runs per game (9th in the MLB) on a .233 /.300/.392 slash line. Regarding pitching, the Orioles’ staff has a 4.44 ERA (23rd) and 1.42 WHIP (27th). Cedric Mullins leads the Orioles with a .308 batting average, four home runs, and 17 RBI this season.

The projected starting pitcher for the Red Sox is Tomoyuki Sugano, who is 1-1 in three starts this season, with a 3.86 ERA and 1.40 WHIP in 14.0 innings.

Total Runs Facts

  • Each of the last six games between the Guardians and Orioles have gone OVER the total runs line.
  • Six of the Guardians' last seven night games against American League opponents have gone OVER the total runs line.
  • The 'Inning 1 UNDER 0.5 runs' market has hit in nine of the Orioles' last 10 games as home underdogs.
  • The 'Inning 1 OVER 0.5 runs' market has hit in seven of the Guardians' last eight games as road favorites against American League opponents.

Matchup/League Facts

  • The Orioles rank T26th in the league for walks this season (48).
  • The Orioles rank 5th in the league for walks allowed this season (52).
  • The Guardians rank T25th in the league for hits this season (124).
  • The Guardians rank 6th in the league for strikeouts against this season (138).

Orioles vs Guardians Prediction

The Orioles won three of the last five H2H encounters. Tanner Bibbee is not a bad starting pitcher, but I think the Orioles will cause him trouble in the opening few innings. Houck allowed a .308 BA in 26 at-bats. Sugano is better at the moment, but given that seven of the previou ten game went Over. I am going with another Over here.

The pick in this article is the opinion of the writer, not a PickDawgz site consensus.

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