Philadelphia Phillies vs St. Louis Cardinals Prediction 4/13/25 MLB Picks

St. Louis Cardinals Betting Preview

The St. Louis Cardinals are 6-8 on the year and play the Astros, Mets, and Braves next. The St. Louis Cardinals are batting .278 on the season, have a .351 OBP, and a .422 slugging percentage. The St. Louis Cardinals pitching staff has a 4.79 ERA and a 1.25 WHIP. Brendan Donovan leads the St. Louis Cardinals with 20 hits and 10 RBI while Lars Nootbaar and Nolan Arenado have combined for 28 hits and 12 RBI.

Matthew Liberatore gets the ball for the St. Louis Cardinals, and he is 0-1 with a 5.84 ERA and 11 strikeouts this season. Liberatore is 0-0 with a 4.35 ERA and 13 strikeouts in his career against the Philadelphia Phillies.

Why the St. Louis Cardinals will win

• The Cardinals have won eight of their last nine games as home underdogs following a home loss.
• The Phillies have lost five of their last six games as road favorites following a win.
• The Cardinals have covered the run line in 11 of their last 12 games as underdogs following a home loss.
• The Phillies have failed to cover the run line in six of their last seven road games against National League opponents following a win.
• The Phillies have trailed after 5 innings in three of their last four games against NL Central opponents that held a losing record.

Why the Philadelphia Phillies will win

• The Phillies have won five of their last six day games against National League opponents that held a losing record.
• The Cardinals have lost four of their last five day games against National League opponents.
• The Phillies have covered the run line in five of their last six day games against National League opponents that held a losing record.
• The Cardinals have failed to cover the run line in five of their last six home games against NL East opponents.
• The Phillies have led after 3 innings in each of their last three day games against NL Central opponents.
• The Cardinals have trailed after 5 innings in three of their last four day games at Busch Stadium against NL East opponents.
• The Phillies have won the first inning in three of their last four games as favorites against NL Central opponents.

Philadelphia Phillies vs St. Louis Cardinals Prediction

The Phillies have cooled off over the last week after a hot start, but I’m still leaning in their direction in this spot. The Cardinals are looking more and more like the team we thought we’d see this season, and Liberatore hasn’t been great up to this point with his career ERA over five and a 1.41 WHIP. Wheeler is an above-average pitcher and he’s holding current Cardinals to a .222 batting average with 16 strikeouts in 72 at bats. The Phillies should win this game and of course, I’ll lay the RL to shave down the expensive juice.