Red Sox vs White Sox Prediction 4/12/25 MLB Picks

Chicago White Sox Betting Preview

The Chicago White Sox are 3-10 this season after they won game one in this series by a score of 11-1 on Friday night. Chicago scored the first seven runs in the game and they tacked on the last three after Boston cut the lead to 7-1 in the seventh. The White Sox recorded 12 hits and they committed one error in the game, while they were led by Narvaez, who went 1-3 with three RBIs in the win. Chicago started Martin, who allowed six hits and one earned run over 6.0 innings, while Booser, Murfee, and Eisert threw three shutout innings in relief. 

Prior to this series, the White Sox were swept by the Guardians in three games and by the Tigers in three games. The Chicago pitching staff has a 3.72 ERA with a 1.27 WHIP and a .217 opponent batting average, while the offense has scored 46 runs with a .211 batting average and a .284 on base percentage this season. Nick Maton has led Chicago with two home runs and two RBIs, while Brooks Baldwin has added one home run and six RBIs this year. The projected starting pitcher for Chicago is Martin Perez, who is 1-0 with a 0.73 ERA and a 0.73 WHIP over 12.1 innings pitched this season. 

Why the White Sox will beat the Red Sox

• The Red Sox have lost four of their last five games as favorites against American League opponents.
• The White Sox have won eight of their last 12 games as home underdogs.
• The White Sox have covered the run line in each of their last seven day games against American League opponents following a win.
• The Red Sox have failed to cover the run line in each of their last five games as favorites.
• The White Sox have led after 5 innings in each of their last four day games against the Red Sox at Rate Field.
• The Red Sox have trailed after 3 innings in three of their last four road games against opponents that held a losing record.

Why the Red Sox will beat the White Sox 

• The White Sox have lost each of their last seven games against American League opponents that held a losing record.
• The Red Sox have won 10 of their last 12 games at Rate Field following a road loss.
• The White Sox have failed to cover the run line each of their last five games against AL East opponents that held a losing record.
• The Red Sox have covered the run line in 10 of their last 12 games at Rate Field following a road loss.
• The Red Sox have led after 5 innings in four of their last five day games against AL Central opponents.

Total Runs Facts

• Four of the Red Sox's last five day games against AL Central opponents have gone UNDER the total runs line.
• Four of the last five games between the Red Sox and White Sox at Rate Field have gone OVER the total runs line.
• The 'Inning 1 UNDER 0.5 runs' market has hit in each of the Red Sox's last six games as road favorites.
• The 'Inning 1 UNDER 0.5 runs' market has hit in each of the last six day games between the Red Sox and White Sox at Rate Field.

Chicago White Sox Player Prop Facts

• Martin Perez has recorded a win in four of his last five appearances against AL opponents that held a losing record.
• Martin Perez has recorded five or more strikeouts in each of his last four home appearances against AL opponents that held a losing record.
• Omar Narvaez has hit a home run in four of his last six appearances with his team as an underdog against the Red Sox.
• Andrew Benintendi has recorded at least one hit in each of his last 11 appearances at Rate Field against opponents that held a losing record.
• Omar Narvaez has recorded at least one RBI in each of his last five home appearances against AL East opponents that held a losing record.
• Andrew Benintendi has recorded at least one Single in eight of his last nine appearances against opponents that held a losing record.
• Josh Rojas has scored at least one run in five of his last six appearances at Rate Field against AL opponents that held a losing record.

Boston Red Sox Player Prop Facts

• Jarren Duran has hit a home run in three of the Red Sox's last six day games against opponents that held a losing record.
• Jarren Duran has recorded at least one RBI in four of the Red Sox's last five day games.
• Jarren Duran has scored at least one run in five of the Red Sox's last six day games against AL opponents that held a losing record.
• Alex Bregman has recorded at least one hit in each of his last eight appearances with his team as a road favorite against AL Central opponents.
• Masataka Yoshida has recorded a Double in each of his last three appearances in day games against AL Central teams that held a losing record.
• Connor Wong has recorded at least one Single in each of his last five appearances at Rate Field against opponents that held a losing record.

Red Sox vs White Sox Prediction 

Boston comes into this game continuing to struggle offensively and they have scored two runs or fewer in four of their last five games. The Red Sox will now have to face Martin Perez, who has been fantastic so far this year and has allowed one earned run and four hits in 12.1 innings this season. Chicago only has three wins on the year, but they erupted for 11 runs on Friday and will face Fitts, who did allow four walks last time out, but has been decent. I think we are going to see a lower scoring game here, as Perez continues to deal, so give me the under here.