Philadelphia Phillies vs St. Louis Cardinals Prediction 4/12/25 MLB Picks

St. Louis Cardinals Betting Preview

The St. Louis Cardinals are 6-7 on the year and play the Astros, Mets, and Braves next. The St. Louis Cardinals are batting .278 on the season, have a .353 OBP, and a .429 slugging percentage. The St. Louis Cardinals pitching staff has a 4.85 ERA and a 1.25 WHIP. Brendan Donovan leads the St. Louis Cardinals with 19 hits and 10 RBI while Lars Nootbaar and Nolan Arenado have combined for 27 hits and 12 RBI.

Miles Mikolas gets the ball for the St. Louis Cardinals, and he is 0-1 with a 11.25 ERA and 4 strikeouts this season. Mikolas is 2-4 with a 4.29 ERA and 27 strikeouts in his career against the Philadelphia Phillies.

Why the St. Louis Cardinals will win

• The Cardinals have won seven of their last eight games as home underdogs.
• The Phillies have lost five of their last seven games as road favorites against NL Central opponents.
• The Cardinals have covered the run line in each of their last eight games as underdogs after playing the previous day.
• The Phillies have failed to cover the run line in four of their last five games at Busch Stadium against teams that held a losing record.
• The Phillies have trailed after 5 innings in four of their last five games as road favorites against National League opponents.

Why the Philadelphia Phillies will win

• The Cardinals have lost eight of their last nine home games against the Phillies following a win.
• The Phillies have won 15 of their last 17 games against the Cardinals following a loss.
• The Phillies have covered the run line in four of their last five day games against teams that held a losing record.
• The Cardinals have failed to cover the run line in four of their last five home games against NL East opponents.

Philadelphia Phillies vs St. Louis Cardinals Prediction

The Phillies have scored a combined two runs in their last two games and that lineup is too talented to stay down for long. Sanchez has also been respectable through 11 innings, allowing five runs and striking out 16. The Cardinals are coming back to earth after a sweep of the Twins, and their pitching has been getting drilled. Mikolas is a two-time all-star, so we know what he’s capable of, but he’s allowed 13 hits and 10 earned runs in eight innings. Mikolas wasn’t good last year either with a 5.35 ERA and 1.28 WHIP. The price is reasonable and the Phillies will have a field day offensively if Mikolas doesn’t get his act together. Give me the Phillies on Saturday afternoon.