Los Angeles Angels vs Houston Astros Prediction 4/12/25 MLB Picks

Houston Astros (6-7) vs Los Angeles Angels (8-5)

Game Info: Saturday, April 12, 2025 at 7:10 pm (Daikin Park)

T. Anderson (L) vs R. Gusto (R)

Betting Odds: Houston Astros -148 / Los Angeles Angels +124 --- Over/Under: 9 Click Here for the Latest Odds

Where to Watch: MLB.TV

The Los Angeles Angels and the Houston Astros meet Saturday in MLB action from Daikin Park. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Los Angeles Angels vs. Houston Astros prediction.

Starting Pitching Matchup

Tyler Anderson will start this game for the Angels and is 0-0 with a 4.50 ERA and 9 strikeouts this season. In his last five starts against the Astros, Anderson is 1-4 with a 6.49 ERA and 21 strikeouts. Ryan Gusto will get the start for the Astros here and is 1-0 with a 1.13 ERA and 9 strikeouts this season. This will be Gusto’s first career start against the Angels.

Los Angeles Angels Recap

The Los Angeles Angels come into this game looking to bounce back after ending up on the wrong side of a 14-3 loss at the hands of the Astros in Friday’s series opener. After this set, the Angels will head on the road for another division series against the Texas Rangers.

Angels Win 5 Of Their Last 7 Despite Loss

Logan O’Hoppe has 14 hits including a team-high 5 home runs and 9 RBIs while Nolan Schanuel has 14 hits with 3 doubles, a triple and 5 RBIs. Luis Rengifo has a team-high 4 doubles with his 11 hits and Taylor Ward also has 12 hits as well while Mike Trout’s added 6 home runs and 12 RBIs so far this season. Jorge Soler also has 3 home runs, but also has the unfortunate distinction of leading the Angels with 18 strikeouts so far this season. Kyren Paris has also chipped in 13 hits with a triple, 5 home runs and 8 RBIs.

Why the Los Angeles Angels will win

  • The Astros have lost each of their last five games as favorites following a win.
  • The Angels have won four of their last six games as underdogs.
  • The Astros have failed to cover the run line in each of their last nine home games after playing the previous day.
  • The Angels have covered the run line in five of their last six games against teams that held a losing record.

Los Angeles Angels Player Prop Facts

  • Mike Trout has hit at least one home run in each of the Angels' last two games as underdogs.
  • Jorge Soler has recorded at least one RBI in 13 of his last 16 road appearances against opponents that held a losing record.
  • Tyler Anderson has recorded five or more strikeouts in four of his last five appearances in night games against teams that held a losing record.
  • Nolan Schanuel has recorded at least one hit in each of the Angels' last 14 games as road underdogs.
  • Anthony Rendon has scored a run in each of his last six appearances with the Angels as underdogs against the Astros.
  • Nicky Lopez has recorded at least one Single in each of his last four appearances in night games against AL West teams that held a losing record.
  • Mike Trout ranks T1st in the league in Home Runs (6) this season.

Houston Astros Recap

The Houston Astros will be out to keep the offensive momentum going after starting the series with a blowout win over the Angels on Friday. After this series, the Astros will head on the road for a series against the St. Louis Cardinals.

Astros Still Looking For Consistency After Alternating Wins & Losses In 8 Straight

Jose Altuve leads the Astros with 19 hits including 3 home runs and 6 RBIs. Jeremy Pena also has a pair of homers and 4 stolen bases while Yordan Alvarez has a double and a team-high 9 RBIs with 13 strikeouts as well. Brendan Rodgers has a pair of doubles while Jake Meyers has a pair of doubles as well and Christian Walker has also accrued a team-high 18 strikeouts so far this season. Altuve also has 3 stolen bases while Jake Meyers has a team-high 5 stolen bases this season.

Why the Houston Astros will win

  • The Angels have lost each of their last nine night games against AL West opponents.
  • The Astros have won seven of their last eight games against the Angels.
  • The Astros have covered the run line in each of their last eight night games against AL West opponents following a win.
  • The Angels have failed to cover the run line in each of their last seven night games following a road loss.

Houston Astros Player Prop Facts

  • Isaac Paredes has hit a home run in three of his last four appearances in night games against AL West teams that held a winning record.
  • Yainer Diaz has recorded at least one Double in each of the Astros' last three games against the Angels.
  • Christian Walker has recorded at least one RBI in each of his last four home appearances against AL West opponents.
  • Yainer Diaz has scored at least one run in each of the Astros' last five games against the Angels.
  • Jose Altuve has recorded at least one Single in each of the Astros' last seven games as favorites.
  • Jeremy Pena has recorded at least one hit in each of his last 17 appearances against the Angels.
  • Jose Altuve ranks T3rd in the league in Hits (19) this season.

Total Runs Facts

  • Each of the Angels' last six night games after playing the previous day have gone OVER the total runs line.
  • Each of the Astros' last four games as favorites have gone OVER the total runs line.

Los Angeles Angels vs. Houston Astros Prediction

I’m leaning towards the Astros. Maybe Friday’s win was what the doctor ordered for the Astros to get back on track and the Astros historically have been a solid team to back against left-handed pitching, which they’ve barely seen any of this season. Anderson is a pitcher that normally gives up a lot of runs and a lot of hard contact and I could see him getting hit hard once again by the Astros here. Give me Houston at home here.

Chris’s Pick Houston Astros -148

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The pick in this article is the opinion of the writer, not a PickDawgz site consensus.

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