Houston Astros vs Seattle Mariners Prediction 4/7/25 MLB Picks

The projected starting pitcher for the Astros is Hayden Wesneski, who has a 0-1 record in one start this year with a 5.40 ERA and 1.00 WHIP in 5.0 innings.

Seattle Mariners Betting Preview

The Seattle Mariners (3-7, 3-4 Home) opened the season with a series slip against the Athletics, after which they lost two of three games to the Detroit Tigers and were swept by the San Francisco Giants in a three-game series. Seattle outhit San Francisco 11-7 in the latest game, but the Giants won 5-4. Bryan Woo pitched for 6.0 innings in a no-decision after allowing four runs on five hits with six strikeouts and one walk, while Gregory Santos took a loss.

This year, the Mariners average 3.20 runs per game (28th in the MLB) on a .213/.320/.354 triple-slash. When it comes to pitching, the Mariners’ staff has a 4.58 ERA (21st) and 1.40 WHIP (24th). Jorge Polanco leads the Orioles with a .450 batting average, two home runs, and eight RBI this season.

Logan Gilbert will take the mound for the Mariners on Monday. The 27-year-old right-hander has a 0-1 record in two starts this year with a 3.00 ERA and 0.67 WHIP over 12.0 innings of work.

Why the Mariners will beat the Astros

• The Astros have lost each of their last four games following a win.
• The Mariners have won six of their last seven home games against AL West opponents that held a losing record.
• The Astros have failed to cover the run line in eight of their last nine games at T-Mobile Park against American League opponents that held a losing record.
• The Mariners have covered the run line in five of their last six games following a road loss.
• The Astros have trailed after 5 innings in three of their last four night games.
• The Astros have lost the first inning in three of their last four road games against American League opponents.

Total Runs Facts

• Each of the Astros' last seven night games as underdogs have gone UNDER the total runs line.
• Nine of the Mariners' last 11 games as favorites against the Astros have gone UNDER the total runs line.
• The 'Inning 1 UNDER 0.5 runs' market has hit in each of the Mariners' last eight games against AL West opponents.
• The 'Inning 1 UNDER 0.5 runs' market has hit in each of the Astros' last five games as road underdogs against AL West opponents.

Astros vs Mariners Prediction

The Mariners won six of the previous ten H2H encounters, including three of the last four. Logan Gilbert has an advantage here after posting a 3.60 ERA in 20.0 innings against the Astros last year, while Wesneski allowed a .375 BA in 16 at-bats against the Mariners. The Astros have been very weak offensively so far in the season and are facing the best Mariners pitcher. I am backing Seattle to take the win.