St. Louis Cardinals vs Boston Red Sox Prediction 4/6/25 MLB Picks

Miles Mikolas will take the mound for the Cardinals on Sunday. The 36-year-old righty had a 10-11 record in 32 starts last year with a 5.35 ERA and 1.28 WHIP in 171.2 innings. This season, Mikolas pitched 5.1 innings with a 3.38 ERA in a no-decision against the Angels.

Boston Red Sox Betting Preview

The Boston Red Sox (4-4, 1-0 Home) lost the opening series of the season to the Texas Rangers but responded with two wins in three games over the Baltimore Orioles. The Red Sox won their first home game of the campaign by defeating the Cardinals 13-9. Trevor Story led the team offensively with three RBI, while Walker Buehler recorded a win after allowing five runs on seven hits with four strikeouts and one walk over 5.0 innings of work.

This season, the Red Sox average 5.00 runs per game (8th in the MLB) on a .256/.335/.415 slash line. Regarding pitching, the Red Sox’s staff has a 4.24 ERA (14th) and 1.25 WHIP (16th). Wilyer Abreu leads the Red Sox with a .500 batting average, three home runs, and eight RBI this season.

The Red Sox didn't announce the starting pitcher at the time of writing.

Why the Cardinals will beat the Red Sox

• The Cardinals have won eight of their last 10 games as underdogs following a loss.
• The Red Sox have lost nine of their last 10 games against National League opponents that held a winning record.
• The Cardinals have covered the run line in nine of their last 10 games as underdogs.
• The Red Sox have failed to cover the run line in eight of their last nine home games against NL Central opponents following a home win.

Why the Red Sox will beat the Cardinals

• The Red Sox have won nine of their last 10 day games against NL Central opponents.
• The Cardinals have lost each of their last four games against AL East opponents.
• The Red Sox have covered the run line in five of their last six games.
• The Cardinals have failed to cover the run line in three of their last four games against American League opponents.
• The Cardinals have trailed after 5 innings in three of their last four road games against American League opponents.
• The Red Sox have won the first inning in three of their last four day games at Fenway Park.
• The Cardinals have trailed after 3 innings in each of their last three games against American League opponents.

Total Runs Facts

• Seven of the Red Sox's last eight games as favorites against the Cardinals have gone OVER the total runs line.
• Each of the Cardinals' last five games have gone OVER the total runs line.
• The 'Inning 1 OVER 0.5 runs' market has hit in each of the Cardinals' last five day games.
• The 'Inning 1 OVER 0.5 runs' market has hit in six of the last seven games between the Cardinals and Red Sox.

Cardinals vs Red Sox Prediction

The Cardinals won six of the previous ten H2H encounters, but the Red Sox were better in the last two. Miles Mikolas didn't impress in his first start of the season, and I don't think he will improve in Boston. It's the second game of a doubleheader, and we still don't know who will start for the Red Sox, but whoever starts will face issues against the Cardinals, one of the best offenses in the MLB early in the season. Eight of the previous ten H2H duels went Over, while eight of the last ten St. Louis' games also went Over. I am backing Over.