Seattle Mariners vs San Francisco Giants Prediction 4/6/25 MLB Picks

Bryan Woo will take the mound for the Mariners on Sunday. The 25-year-old righty had a 9-3 record in 22 starts last year with a 2.89 ERA and 0.90 WHIP in 121.1 innings. This season, Woo is 1-0 with a 1.50 ERA in 6.0 innings.

San Francisco Giants Betting Preview

The San Francisco Giants (7-1, 2-0 Home) came home from a road trip to Cincinnati and Houston and beat the Seattle Mariners in the opening two games of a three-game series. The Giants won two of three games against the Reds and, surprisingly, swept the Astros before defeating the Mariners 10-9 and 4-1. In the latest win, Matt Chapman led the team with two RBI, while Robbie Ray got a win after allowing one run on four hits with two strikeouts and five walks over 6.0 innings of work.

This season, the Giants average 5.50 runs per game (5th in the MLB) on a .241/.313/.432 slash line. Regarding pitching, the Giants’ staff has a 2.71 ERA (4th) and 1.20 WHIP (13th). Wilmer Flores leads the Giants with a .250 batting average, four home runs, and 11 RBI this season.

The projected starting pitcher for the Giants is Jordan Hicks, who had a 4-7 record in 20 starts last year with a 4.10 ERA and 1.45 WHIP in 109.2 innings. Hicks is 1-0 this season, with a 0.00 ERA in 6.0 innings.

Why the Mariners will beat the Giants

• The Mariners have won each of their last five day games following a loss.
• The Giants have lost 11 of their last 14 games as favorites against American League opponents following a home win.
• The underdogs have covered the run line in seven of the Mariners' last eight games.
• The Giants have failed to cover the run line in each of their last four day games following a home win.

Why the Giants will beat the Mariners

• The Giants have won each of their last seven games against American League opponents following a win.
• The Mariners have lost each of their last five road games against NL West opponents.
• The Giants have covered the run line in 10 of their last 11 games against American League opponents after playing the previous day.
• The Mariners have failed to cover the run line in seven of their last eight games as underdogs against NL West opponents following a road loss.
• The Mariners have trailed after 5 innings in each of their last five games against opponents that held a winning record.

Total Runs Facts

• Five of the Mariners' last six games after playing the previous day have gone UNDER the total runs line.
• Four of the Giants' last five day games as favorites have gone OVER the total runs line.
• The 'Inning 1 OVER 0.5 runs' market has hit in seven of the Mariners' last eight day games against National League opponents.
• The 'Inning 1 OVER 0.5 runs' market has hit in each of the last four day games between the Mariners and Giants.

Mariners vs Giants Prediction

The teams have traded victories over the past few years, as each recorded five wins in the last ten games. The Giants were better in the previous three H2Hs. Bryan Woo dominated the Giants last year as he allowed a 1.29 ERA in 7.0 innings and had a .148 BA in 27 at-bats. Jordan Hicks struggled in his previous game against Seattle; he didn't complete a single innings as he came in as a reliever and posted a 13.50 ERA. Bth Woo and Hicks were impressive in their first respective starts of this season, and I am backing them to have another strong outing. Both will record quality starts, so I am going with Under.