Houston Astros vs Minnesota Twins Prediction 4/6/25 MLB Picks

Astros Drop 4 Of Their Last 5

Jose Altuve leads the Astros with 12 hits including a pair of solo home runs while also boasting a team-high 11 strikeouts. Jeremy Pena also has a pair of solo homers and a pair of stolen bases while Yordan Alvarez has a double and a team-high 4 RBIs with 11 strikeouts as well. Brendan Rodgers has a pair of doubles and 3 RBIs and Christian Walker has also accrued 11 strikeouts so far this season.

Why the Houston Astros will win

• The Twins have lost each of their last five games as home favorites after playing the previous day.
• The Astros have won five of their last six games as underdogs against AL Central opponents following a loss.
• The Astros have covered the run line in each of their last nine games as underdogs against American League opponents following a loss.
• The Twins have failed to cover the run line in each of their last six day games against the Astros following a win.

Houston Astros Player Prop Facts

• Brendan Rodgers has recorded a Double in four of his last five appearances with his team as an underdog.
• Christian Walker has hit a home run in each of his last two road appearances against the Twins after playing the previous day.
• Jose Altuve has scored at least one run in each of his last eight Sunday appearances against AL Central teams that held a losing record.
• Yordan Alvarez has recorded at least one RBI in each of his last six Sunday appearances against AL Central teams that held a losing record.
• Jose Altuve has recorded at least one Single in each of his last eight Sunday appearances against AL Central teams that held a losing record.
• Jeremy Pena has recorded at least one hit in each of the Astros' last nine games against AL opponents that held a losing record.
• Jose Altuve ranks T5th in the league in Hits (12) this season.

Minnesota Twins Recap

The Minnesota Twins come into the series finale looking to emerge victorious after evening the series up at one win apiece after their triumph in Saturday’s matchup. After this set, the Twins will head on the road to start a divisional series against the Kansas City Royals.

Twins Looking For Back-To-Back Series Wins

Ty France, Byron Buxton, Trevor Larnach and Willi Castro each have 6 hits with Buxton and Castro each logging a home run and three RBIs. Castro and Matt Waller each have a team-high 3 doubles with Wallner adding a triple and Harrison Bader has team-highs of 3 home runs and 8 RBIs as well this season. Buxton’s also got the dubious distinction of leading the Twins with 9 strikeouts so far this season.

Why the Minnesota Twins will win

• The Twins have won seven of their last eight games against AL West opponents following a home win.
• The Astros have lost five of their last six day games against American League opponents.
• The Astros have failed to cover the run line in six of their last seven games.
• The Twins have covered the run line in six of their last seven day games against AL West opponents that held a losing record.

Minnesota Twins Player Prop Facts

• Harrison Bader has hit a home run in two of his last three appearances with the Twins against AL opponents.
• Jose Miranda has recorded at least one RBI in four of his last five appearances against the Astros after playing the previous day.
• Ty France has recorded at least one Single in seven of his last eight appearances against AL West opponents.
• Byron Buxton has scored at least one run in each of his last six home appearances against AL West opponents.
• Trevor Larnach has recorded at least one hit in each of his last seven home appearances against AL West opponents that held a losing record.
• Christian Vazquez has recorded a Double in three of his last four home appearances against AL West opponents.

Total Runs Facts

• Eight of the Astros' last nine games as road underdogs have gone UNDER the total runs line.
• Eight of the Twins' last 10 home games after playing the previous day have gone OVER the total runs line.

Houston Astros vs. Minnesota Twins Prediction

I’m on the Twins in this one. I’ve given the Astros the benefit of the doubt, but maybe I just have to acknowledge that the Astros might be slow starters like they were last season and that’s okay. The Twins have been inconsistent in their own right, and Paddack stunk in his debut but he was solid in his lone start against the Astros and Houston’s offense has just stalled in the early going so far this year as well. Give me Minnesota in this one to win the series going away.