Cleveland Guardians vs Los Angeles Angels Prediction 4/6/25 MLB Picks

Guardians Looking To Rebound

Steven Kwan leads the Guardians with 11 hits as part of a .367 batting average and a home run, a double and three RBIs. Kyle Manzardo has 7 hits with a double, a triple, 2 home runs and a team-high 8 RBIs as well this year. Jose Ramirez, Carlos Santana and Nolan Jones each have a team-high 2 doubles as well this season. Nolan Jones also owns the unfortunate team lead with 10 strikeouts so far this year.

Why the Cleveland Guardians will win

• The Guardians have won each of their last six day games against AL West opponents.
• The Angels have lost seven of their last eight games against teams that held a losing record.
• The Angels have failed to cover the run line in each of their last seven games against American League opponents following a win.
• The Guardians have covered the run line in each of their last four road games against AL West opponents following a road loss.

Cleveland Guardians Player Prop Facts

• Carlos Santana has hit a home run in three of his last four appearances in day games against AL teams that held a winning record.
• Carlos Santana has recorded at least one RBI in each of his last seven road appearances against the Angels after playing the previous day.
• Steven Kwan has scored at least one run in each of the Guardians' last six road games against AL opponents.
• Steven Kwan has recorded at least one Single in each of the Guardians' last nine games as road favorites against AL opponents.
• Steven Kwan has recorded at least one hit in each of the Guardians' last 12 road games against AL opponents.
• Will Brennan has recorded at least one Double in each of his last three appearances with the Guardians as favorites against AL opponents.
• Jose Ramirez ranks T4th in the league in Home Runs (4) this season.

Los Angeles Angels Recap

The Los Angeles Angels come into this game looking to win the set after picking up the W in Saturday’s matchup to improve to 5-3 on the year. After this series, the Angels will head on the road for a series against the Tampa Bay Rays.

Angels Looking For Third Straight Series Win To Start The Year

Nolan Schanuel has a team-high 9 hits with a double, a triple and 4 RBIs while Logan O’Hoppe has a team-high 4 home runs and 8 RBIs as well on the year. Mike Trout’s added 3 home runs and 8 RBIs of his own while Luis Rengifo and Yoan Moncada each have 2 doubles as well on the year. Jorge Soler has the dubious distinction of leading the Halos with 12 strikeouts this season.

Why the Los Angeles Angels will win

• The Angels have won seven of their last eight games as underdogs against AL Central opponents following a home win.
• The Guardians have lost seven of their last eight games at Angel Stadium of Anaheim against AL West opponents that held a winning record.
• The Guardians have failed to cover the run line in nine of their last 10 games after playing the previous day.
• The Angels have covered the run line in seven of their last eight games as underdogs against AL Central opponents following a home win.

Los Angeles Angels Player Prop Facts

• Logan O'Hoppe has hit a home run in each of the Angels' last four games as home underdogs against AL Central opponents.
• Nolan Schanuel has scored a run in each of the Angels' last six games as home underdogs against AL Central opponents.
• Mike Trout has recorded at least one RBI in eight of his last nine appearances with the Angels as underdogs.
• Tim Anderson has recorded at least one Single in each of his last 12 Sunday appearances against AL Central teams that held a losing record.
• Nolan Schanuel has recorded at least one hit in each of his last 15 appearances with the Angels as underdogs.
• Yoan Moncada has recorded a Double in each of his last three home appearances against opponents that held a losing record.
• Logan O'Hoppe ranks T4th in the league in Home Runs (4) this season.

Total Runs Facts

• Each of the Angels' last five games have gone OVER the total runs line.
• Each of the Guardians' last four games as favorites have gone OVER the total runs line.

Angels vs Guardians Prediction

I’m on the Guardians here. I just don’t trust Tyler Anderson as a starter, as he had one good year with the Dodgers, but this is a guy that every year finishes the season with an ERA in the high fours or low fives. He just gives up runs in bunches. The Angels have swung a hot bat to start the year, but in the end, I just think the Guardians are the better all around team to get the win on the road to take the series. Give me Cleveland in this one.