Seattle Mariners vs San Francisco Giants Prediction 4/5/25 MLB Picks

-Recent Betting trends and streaks involving Seattle

-Recent Betting trends and streaks involving San Francisco

-Recent betting trends in games played between San Francisco and Seattle

-A summary that ties it all together produces a favorable betting outcome for Today’s Game between the Giants and Mariners. 

Mariners Fell Just Short

The Mariners were competitive on Friday against the San Francisco Giants but fell short in extra innings. It was a back-and-forth game, and they finished with 15 runs, but they still fell short. Jorge Polanco was the bright spot of the offense, hitting a home run and driving in four RBIs. 

The Mariners did use eight bullpen members, and that has to be a major concern heading into this game. The pitching for this team has been inconsistent at best, giving up 4.87 runs per game. Bryce Miller will end up being on the mound, and he sits with an 0-1 record and an ERA of .476. Against the Athletics in his first start, he went 5.2 innings, giving up six hits and three runs. They need him to go really deep in this game to make up for the tired bullpen that was caused on Friday. 

Why the Mariners Will Beat the Giants

• The Giants have lost six of their last seven games as favorites against AL West opponents following a home win.
• The Mariners have won three of their last four games as underdogs after playing the previous day.
• The road team has covered the run line in 15 of the Giants' last 16 games.
• The Giants have failed to cover the run line in nine of their last 10 night games following an extra-innings win.

Strong Start for the Giants

It has been a strong start for the Giants, and coming into this game, they sit with a 6-1 record overall. On Friday, they scored 10 runs and 17 hits, and that was enough to pick up the win. Matt Chapman had quite the game, hitting a home run and driving in two RBIs. Willy Adames also finished with three hits and three RBIs. Two games ago, against the Houston Astros, the Giants picked up a 6-3 victory. 

The Giants' offense has been strong all season, averaging 5.71 runs per game, which is fifth best in the league. Robbie Ray will start this game for the Giants. He has a 1-0 record and an ERA of 5.86. Against the Cincinnati Reds, he went 5.1 innings, giving up three hits and three runs. 

Why the Giants Will Beat the Mariners

• The Giants have won nine of their last 10 games against American League opponents.
• The Mariners have lost each of their last four night games after playing the previous day.
• The Giants have covered the run line in each of their last six games against American League opponents after playing the previous day.
• The Mariners have failed to cover the run line in six of their last seven games after playing the previous day after going to extra innings.
• The Mariners have trailed after 5 innings in each of their last five night games.
• The Mariners have trailed after 3 innings in three of their last four night games against NL West opponents.

Seattle Mariners vs San Francisco Giants Prediction

Friday was a high-scoring game, and I am expecting much of the same here. The bullpens for these teams are taxed, and when both of these pitchers are chased early, it’s going to make for a high-scoring game. Robbie Ray wasn’t dominant in his last start, and he’s going to be lit up here. The Marienrs will get out to a fast start, and they will cruise. The Mariners' pitching will also struggle, and this game will end up over the total. Back the over.