St. Louis Cardinals vs Boston Red Sox Prediction 4/4/25 MLB Picks

Boston Red Sox Betting Preview

The Boston Red Sox are 3-4 on the year and play the Blue Jays, White Sox, and Rays next. The Boston Red Sox are batting .229 on the season, have a .303 OBP, and a .371 slugging percentage. The Boston Red Sox pitching staff has a 3.81 ERA and a 1.19 WHIP. Kristian Campbell leads the Boston Red Sox with 10 hits and 4 RBI while Alex Bregman and Wilyer Abreu have combined for 17 hits and 9 RBI.

Walker Buehler gets the ball for the Boston Red Sox, and he is 0-1 with a 8.31 ERA and 3 strikeouts this season. Buehler is 2-0 with a 2.88 ERA and 31 strikeouts in his career against the St. Louis Cardinals.

Why the Boston Red Sox will win

• The Cardinals have lost eight of their last nine road openers.
• The Red Sox have won each of their last three day games against NL Central opponents.
• The Red Sox have covered the run line in eight of their last 10 games against teams that held a winning record.
• The Cardinals have failed to cover the run line in four of their last five road openers as underdogs.
• The Red Sox have led after 5 innings in each of their last four games at Fenway Park against opponents that held a winning record.

Why the St. Louis Cardinals will win

• The Red Sox have lost each of their last six games as favorites against NL Central opponents following a road win.
• The Cardinals have won each of their last four games as underdogs.
• The Red Sox have failed to cover the run line in each of their last seven games against National League opponents.
• The Cardinals have covered the run line in 10 of their last 11 games as underdogs.
• The Cardinals have led after 5 innings in four of their last five road games against opponents that held a losing record.

St. Louis Cardinals vs Boston Red Sox Prediction

The Cardinals are off to a solid start through six games, but they’re just not a team I trust to continue the success. The Red Sox are coming off two nice road wins over the Orioles to kind of right the ship, and now they come home for their opening day home game. Rafael Devers is hitting the ball again and Fenway is sure to have some juice on Friday afternoon. Buehler also can’t pitch any worse than he did in his season debut, and I’m sure he wants to make a good impression for his new team. It’s been a struggle for Buehler in his last 17 games, and he’s shown in past years he’s better than that. I’ll lay the reasonable price with the Red Sox at home.