Cleveland Guardians vs Los Angeles Angels Prediction 4/4/25 MLB Picks

Los Angeles Angels Betting Preview

The Los Angeles Angels are 4-2 on the year and play the Rays, Astros, and Rangers next. The Los Angeles Angels are batting .198 on the season, have a .267 OBP, and a .310 slugging percentage. The Los Angeles Angels pitching staff has a 4.58 ERA and a 1.38 WHIP. Nolan Schanuel leads the Los Angeles Angels with 7 hits and 3 RBI while Taylor Ward and Kyren Paris have combined for 10 hits and 4 RBI.

Jose Soriano gets the ball for the Los Angeles Angels, and he is 1-0 with a 0.00 ERA and 5 strikeouts this season. Soriano is 2-1 with a 2.77 ERA and 11 strikeouts in his career against the Cleveland Guardians.

Why the Los Angeles Angels will win

• The Guardians have lost each of their last six games at Angel Stadium of Anaheim against teams that held a winning record.
• The Angels have won five of their last six home games against AL Central opponents following a road loss.
• The Guardians have failed to cover the run line each of their last six games at Angel Stadium of Anaheim against teams that held a winning record.
• The Angels have covered the run line in seven of their last eight games as home underdogs against AL Central opponents.

Why the Cleveland Guardians will win

• The Angels have lost 12 of their last 13 night games against American League opponents.
• The Guardians have won five of their last six road games against AL West opponents.
• The Angels have failed to cover the run line in each of their last seven games as home underdogs against American League opponents following a road loss.
• The Guardians have covered the run line in four of their last five road games against AL West opponents following a loss.
• The Angels have trailed after 3 innings in three of their last four home openers against American League opponents.
• The Guardians have led after 5 innings in three of their last four night games against the Angels at Angel Stadium of Anaheim.

Cleveland Guardians vs Los Angeles Angels Prediction

I’ve been harsh on the Angels, as they’ve been a joke of a franchise over the last decade and have wasted careers, but they’re off to a decent start this season. The Guardians have scored a combined four runs in their last three games and have been held to three or fewer runs in four of their last five games. Battle of the third-year pitchers, it’s Soriano who has shown more promise and that includes pitching seven scoreless innings against the White Sox in his season debut. Williams has had far more ups and downs, and he’s had a control issue as well with 70 walks in 163 career innings. With a pick 'em price, it’s hard to go against the Angels at home.