Cardinals vs Mariners Prediction - MLB Picks 4/22/23

Seattle Mariners (9-11) vs St. Louis Cardinals (8-12)

Game Info: Saturday, April 22, 2023 at 9:40 pm (T-Mobile Park)

Luis Castillo (2-0) (0.73) vs Miles Mikolas (0-1) (8.10)

Betting Odds: Seattle Mariners -160 / St. Louis Cardinals +130 --- Over/Under: 8 Click Here for the Latest Odds

Where to Watch: Stream the MLB Game of the Day all season on ESPN+. Sign up now! Advertisement

The St. Louis Cardinals will play the Seattle Mariners in Game 2 of their series on Saturday night at T-Mobile Park in Seattle, Washington.

Cardinals Preview

The St. Louis Cardinals are 8-12 this season and they have lost three of their last four games. Prior to losing Game 1 of this series, St. Louis lost two out of three games against the Diamondbacks. The St. Louis pitching staff has a 4.70 ERA, a 1.47 WHIP, and a .279 opponent batting average this year. The Cardinals offense has scored 93 runs with a .267 batting average and a .345 on base percentage. Nolan Gorman is batting .300 with five home runs and 18 RBI’s for the Cardinals. The projected starting pitcher for St. Louis is Miles Mikolas, who is 0-1 with an 8.10 ERA and a 2.05 WHIP over 20 innings pitched this season.

Mariners Preview

The Seattle Mariners are 9-11 this season and they have lost three of their last four games. Seattle won Game 1 of this series by a score of 5-2 on Friday night. The Seattle pitching staff has a 3.56 ERA, a 1.21 WHIP, and a .222 opponent batting average. The Mariners offense has scored 90 runs with a .228 batting average and a .305 on base percentage this season. Jarred Kelenic is batting .311 with four home runs and 11 RBI’s for the Mariners. The projected starting pitcher for Seattle is Luis Castillo, who is 2-0 with a 0.73 ERA and a 0.61 WHIP over 24.2 innings pitched this year. 


St. Louis is 6-2 in their last 8 interleague games and 38-18 in their last 56 Saturday games. The under is 5-2 in St. Louis’ last 7 game two’s of a series. Seattle is 5-2 in their last 7 Saturday games and 29-12 in their last 41 game two’s of a series. The over is 5-1 in Seattle’s last 6 game two’s of a series. The under is 8-3-1 in these two teams last 12 head to head meetings.


Both of these teams have struggled in their last few games, but Seattle was able to get the win in Game 1 of this series. The Mariners will look to make it two in a row with Luis Castillo on the mound, who has been fantastic this year. The Cardinals will start Miles Mikolas, who has allowed at least five earned runs in three of his four starts this year. I like the Mariners to win this game behind another great outing from Castillo. 

David’s Pick Mariners ML

Get Premium Picks Start Winning Now »
The pick in this article is the opinion of the writer, not a PickDawgz site consensus.

Mitch's Take...

MLB Picks & Predictions Today 7/20/24 | Ron's Rundown

18+ Has gambling become a problem for you? Call the National Problem Gambling Hotline.
1-800-522-4700 |

Credit Guaranteed Packages

Packages with Credit Guarantees automatically give you a credit if the package does not turn a profit—the sum of betting all individual picks. THESE ARE NOT PARLAYS UNLESS OTHERWISE CLEARLY STATED. If a credit guaranteed package does not profit, a credit for its full purchase price is automatically issued after picks are graded and verified.

For example, if you purchase a $39.95 package that doesn’t profit, you’ll get a $39.95 credit towards any future purchase(s) on our site. Credits are usually issued within hours of a game’s conclusion, so please allow a few hours for final verification.

To use your credits, log in to your account and add another package or pass to your cart. Credits will automatically reduce what you owe. Any remaining balance will be settled through our payment system, with any leftover credits available future purchases. Credits do not expire.