Reds vs Pirates Prediction - MLB Picks 4/21/23

Pittsburgh Pirates (13-7) vs Cincinnati Reds (7-12)

Game Info: Friday, April 21, 2023 at 6:35 pm (PNC Park)

Mitch Keller (1-0) (3.80) vs Graham Ashcraft (2-0) (1.42)

Betting Odds: Pittsburgh Pirates -130 / Cincinnati Reds +110 --- Over/Under: 8.5 Click Here for the Latest Odds

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The Cincinnati Reds will play the Pittsburgh Pirates in Game 2 of their series on Friday night at PNC Park in Pittsburgh, Pennsylvania.

Reds Preview

The Cincinnati Reds are 7-12 this season and they have lost four of their last five games. Prior to losing Game 1 of this series, Cincinnati lost two out of three games against Tampa Bay. The Cincinnati pitching staff has a 5.36 ERA, a 1.58 WHIP, and a .286 opponent batting average this year. The Reds offense has scored 85 runs with a .240 batting average and a .324 on base percentage. TJ Friedl is batting .303 with two home runs and nine RBI’s for the Reds. The projected starting pitcher for Cincinnati is Graham Ashcraft, who is 2-0 with a 1.42 ERA and a 1.16 WHIP over 19.0 innings pitched this season.

Pirates Preview

The Pittsburgh Pirates are 13-7 this season and they have won four games in a row. Pittsburgh won Game 1 of this series by a score of 4-3 on Thursday. The Pittsburgh pitching staff has a 4.03 ERA, a 1.41 WHIP, and a .251 opponent batting average. The Pirates offense has scored 103 runs with a .253 batting average and a .331 on base percentage this season. Bryan Reynolds is batting .291 with five home runs and 17 RBI’s for the Pirates. The projected starting pitcher for Pittsburgh is Mitch Keller, who is 1-0 with a 3.80 ERA and a 1.35 WHIP over 23.2 innings pitched this year.

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Cincinnati is 4-11 in their last 15 games and 0-5 in their last 5 Friday games. The over is 4-1 in Cincinnati’s last 5 game two’s of a series. Pittsburgh is 4-0 in their last 4 games and 18-43 in their last 61 Friday games. The over is 5-3-1 in Pittsburgh’s last 9 home games. Cincinnati is 2-9 in these two teams last 11 head to head meetings.


The Pirates have started the season playing very well and they were able to win Game 1 of this series. Cincinnati has struggled in recent games, but will have Graham Ashcraft on the mound, who has only allowed three earned runs over 19.0 innings pitched. The Pirates are starting Mitch Keller, who has allowed five earned runs over his last 12 innings pitched. The Reds have the advantage in starting pitching and I am going to take them to get the win. 

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The pick in this article is the opinion of the writer, not a PickDawgz site consensus.

Mitch's Take...

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