Chicago White Sox at Chicago Cubs: 5/4/22 MLB Picks and Prediction

Chicago White Sox at Chicago Cubs: 5/4/22 MLB Picks and Prediction Photo by Mark J. Rebilas-USA TODAY Sports

Chicago Cubs (9-13) vs Chicago White Sox (9-13)

Game Info: Wednesday, May 4, 2022 at 7:40 pm (Wrigley Field)

Kyle Hendricks (1-2) (5.47) vs Lucas Giolito (0-1) (2.57)

Betting Odds: Chicago Cubs +115 / Chicago White Sox -152 --- Over/Under: Click Here for the Latest Odds

The Chicago White Sox will visit the Chicago Cubs in the second game of their series in the National League West versus American League East matchup from Wrigley Field on Wednesday night. The weather is expected to be very humid with a 0% chance of rain and 8.1 mile per hour winds.

The Chicago White Sox are coming off of a 2 run win against the Chicago Cubs in their last game. Anderson homered and José Abreu made two nice plays at first base to help secure the win. The series is at 1-0 going into game 2 in favor of the White Sox.

Michael Kopech got the start for the Chicago White Sox in this one. He has a 1.17 ERA, with 23 strikes and a 1.04 whip. He pitched four-plus scoreless innings in the win.

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Chicago White Sox right-hander, Lucas Giolito will be the starter for this one. He has a 2.57 ERA, with 22 strikes and a 1.29 whip. 

The Chicago Cubs are coming off of a 2 run loss against the Chicago White Sox in their last game. The series is at 1-0 going into game 2 in favor of the White Sox. 

Scott Effross got the start for the Chicago Cubs in this one. He has a 1.59 ERA, with 12 strikes and a .88 whip. He got four outs in his first big league start, allowing two unearned runs and two hits before calling it a night in the loss. 

Chicago Cubs left-hander, Kyle Hendricks will be the starter for this one. This season he has a 5.47 ERA, with 21 strikes and a 1.50 whip. 

The Cubs are 4-10 in their last 14 interleague games as an underdog. The White Sox are 4-0 in their last 4 interleague road games vs. a right-handed starter and are 4-0 in their last 4 interleague road games vs. a team with a losing record. The White Sox are also 4-0 in their last 4 interleague road games and are 10-1 in their last 11 interleague games. I think the Sox see continued success with a win in this one.

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Clayton’s Pick White Sox ML

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The pick in this article is the opinion of the writer, not a PickDawgz site consensus.

Mitch's Take...

MLB Picks & Predictions Today 8/9/22 | Ron's Rundown

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