San Francisco Giants at Cleveland Guardians: 4/16/22 MLB Picks and Prediction

Cleveland Guardians (4-2) vs San Francisco Giants (4-2)

Game Info: Saturday, April 16, 2022 at 6:10 pm (Progressive Field)

Cal Quantrill (1-0) (3.60) vs Anthony DeSclafani (0-0) (4.91)

Betting Odds: Cleveland Guardians +115 / San Francisco Giants -152 --- Over/Under: 8.5 Click Here for the Latest Odds

The San Francisco Giants will visit the Cleveland Guardians in the second game of their series in the National League West division versus American League Central matchup from Progessive Field on Saturday night. The weather is expected to be pretty humid with a zero chance of rain and 11.9 mile per hour winds.

The San Francisco Giants are coming off of a 3 run win against the Cleveland Guardians in their last game. The Cleveland Guardians lost in their first home game using their new name as Carlos Rodón allowed one run in seven innings and Joey Bart hit a two-run homer in the eighth to lead. The series is in favor of the Giants at 1-0.

Carlos Rodon got the start for the San Francisco Giants in this one. He has a 1.5 ERA, with 21 strikes and a .75 whip. Rodón struck out nine, giving up two hits and a pair of walks as the Giants won their third straight with the win.

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San Francisco Giants right-hander Anthony Desclafani, will be the starter for this one. This season he has a 4.91 ERA. He has 5 strikeouts and a 2.45 whip.

The Cleveland Guardians are coming off of a 3 run loss against the San Francisco Giants in their last game. The series is in favor of the Giants at 1-0.

Zach Plesac got the start for the Cleveland Guardians in this one. He has a 1.64 ERA, with 7 strikes and a 1 whip. He worked 5 1/3 innings before calling it a night.

Cleveland Guardians right-hander, Cal Quantrill will be the starter for this one. This season he has a 3.6 ERA. He had 2 strikeouts and a 1 whip.

The Giants are 5-1 in their last 6 interleague games vs. a right-handed starter and are 4-1 in their last 5 interleague games. The Giants are also 4-1 in their last 5 interleague games as a favorite. The Guardians are 4-13 in their last 17 vs. National League West and are 3-10 in their last 13 home games vs. a right-handed starter. The Guardians are also 6-21 in their last 27 games as a home underdog. I like for San Fran to get the win in what should be a competitive game.

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