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Notre Dame vs Houston Prediction 11/26/2025 Today’s College Basketball Picks

Nov 25, 2025; Las Vegas, NV, USA; Houston Cougars guard Milos Uzan (7) drives to the basket against Tennessee Volunteers guard Ja'Kobi Gillespie (0) in a 2025 Players Era Festival group play game during the first half at MGM Grand Garden Arena. Mandatory Credit: Stephen R. Sylvanie-Imagn Images

Nov 25, 2025; Las Vegas, NV, USA; Houston Cougars guard Milos Uzan (7) drives to the basket against Tennessee Volunteers guard Ja'Kobi Gillespie (0) in a 2025 Players Era Festival group play game during the first half at MGM Grand Garden Arena. Mandatory Credit: Stephen R. Sylvanie-Imagn Images

Houston (6-1) vs Notre Dame (5-2)

03:30 PM EST

The Line: Betting Odds: Houston -10.5 — Over/Under: 132.5

(Get latest betting odds)

In this article we will formulate a Notre Dame vs Houston prediction for this College Basketball game on Wednesday, November 26th at MGM Grand Garden Arena in Las Vegas, Nevada. Let’s take a look at the prediction for this College Basketball matchup.

Notre Dame Fighting Irish Betting Preview

The Notre Dame Fighting Irish are 5-2 this season after they defeated Rutgers by a score of 68-63 in their last game. Notre Dame led 36-24 at halftime, but they were outscored 39-32 in the second half in the win. The Fighting Irish shot 49% from the field, 44% on three pointers, and 67% on free throws in the game. Markus Burton led Notre Dame with 21 points and six rebounds, while Jalen Haralson added 15 points and one assist in the win. 

Prior to that game, Notre Dame lost to Kansas by a score of 71-61, but did beat Bellarmine by a score of 86-79 before that. The Fighting Irish have scored 78.1 points per game with 38.1 rebounds and 11.7 assists per game, while they have allowed 67.4 points against per game this season. Markus Burton is averaging 20.3 points and 2.4 assists per game, while Jalen Haralson is averaging 13.0 points and 3.3 rebounds per game for the Fighting Irish. Notre Dame is shooting 47.9% from the field, 71.3% on free throws, and 37.3% on three pointers this season. 

Houston Cougars Betting Preview

The Houston Cougars are 6-1 this year after they lost to Tennessee by a score of 76-73 in their last game. Houston led 39-35 at halftime, but allowed 41 points in the second half in the loss. The Cougars shot 46% from the field, 38% on three pointers, and 73% on free throws in the game. Kingston Flemings led Houston with 25 points and four rebounds, while Milos Uzan added 17 points and four assists in the loss. 

Prior to that game, Houston defeated Syracuse by a score of 78-74 and Rider by a score of 91-45. The Cougars have scored 76.1 points per game with 39.9 rebounds and 16.4 assists per game, while they have allowed 59.6 points against per game this season. Kingston Flemings is averaging 17.3 points and 5.0 assists per game, while Emanuel Sharp is averaging 16.3 points and 3.4 rebounds per game for the Cougars. Houston is shooting 44.5% from the field, 76.1% on free throws, and 33.0% on three pointers this year. 

Why the Houston Cougars will win

Why the Notre Dame Fighting Irish will win

Total Points Facts

Matchup/League Facts

Notre Dame vs Houston Prediction 

Houston is coming off of a close loss to Tennessee on Tuesday, but they also needed overtime to get by Syracuse before that, so they have had some struggles at this tournament. The Cougars are shooting 44% from the field and their defense has not been as elite as usual. Notre Dame lost by 10 to Kansas in their first game, but bounced back with a decent win over Rutgers yesterday. The Fighting Irish are shooting 48% from the field, but I think they are going to have all sorts of problems scoring here. Take Houston to cover.

David Racey's Pick: Houston -10.5

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