Ole Miss vs Florida Prediction 9/26/2026 Today’s College Football Picks
Chris Ruffolo
Sep 19, 2026; Oxford, Mississippi, USA; Mississippi Rebels quarterback Trinidad Chambliss (6) runs onto the field prior to the game against the Louisiana State Tigers at Vaught-Hemingway Stadium. Mandatory Credit: Petre Thomas-Imagn Images
MATCHUP
Ole Miss Rebels
Florida Gators
Team Records
3-0
3-0
Spread
+3.5 -115
-3.5 -105
Moneyline
+140
-166
Total
Over 59.5 (-102)
Under 59.5 (-118)
Where
Ben Hill Griffin Stadium, Gainesville, FL
When
Saturday, September 26, 2026
Time
03:30 PM EDT
TV
ABC
The Ole Miss Rebels and the Florida Gators meet in week 4 college football action from Ben Hill Griffin Stadium on Saturday. We will look at this from a betting perspective and determine the best bets for this game. Here’s an Ole Miss Rebels vs. Florida Gators Prediction.
Ole Miss Rebels Recap
The Ole Miss Rebels come into this game looking to add on to their 32-24 win over LSU last time out to sit at 3-0 this season. After this game, Ole Miss will head on the road for a game against Vanderbilt.
Rebels Looking To Improve On Rivalry Win
Trinidad Chambliss has thrown for 924 yards, 7 touchdowns and 2 interceptions on 70.0% passing while Kevan Lacy leads Ole Miss in rushing with 191 rushing yards and 2 touchdowns so far this season. Chambliss sits behind Lacy on the ground with 64 yards and 2 TDs. Deuce Alexander leads the Rebels in receiving with 295 yards on 20 catches, while Traylon Ray trails with 171 yards on 11 catches. On defense, Tah’j Butler has a team-high 20 total tackles, while Blake Purchase leads the unit with 1.5 sacks, and Nick Cull recorded 1 interception. Ole Miss’s defense as a whole has combined for 6 sacks and 2 interceptions so far this season.
Florida Gators Recap
The Florida Gators come into this game looking to add on to their 44-39 win over Auburn last time out to sit at 3-0 this season. After this game, Florida will head on the road for a matchup against Missouri.
Gators Looking To Stay Unbeaten
Aaron Philo has thrown for 721 yards, 6 touchdowns and 2 interceptions on 73.4% passing while Jadan Baugh leads Florida in rushing with 458 rushing yards and 8 touchdowns so far this season. Duke Clark sits behind Baugh on the ground with 133 yards and 2 TDs. Vernell Brown III leads the Gators in receiving with 246 yards on 14 catches along with 2 touchdowns, while Dallas Wilson trails with 225 yards on 12 catches along with 2 touchdowns. On defense, Myles Graham has a team-high 20 total tackles, Jayden Woods leads the unit with 3 sacks, and Dijion Johnson, Cormani McClain, and LJ McCray have each recorded 1 interception. Florida’s defense as a whole has combined for 10 sacks and 3 interceptions so far this season.
Ole Miss Rebels @ Florida Gators Betting Trends: Week 4
Why the Florida Gators will win
Florida has won four of its last five games against top-15 AP-ranked teams at Ben Hill Griffin Stadium.
Ole Miss has lost each of its last three games as a top-5 AP-ranked team against an AP-ranked team.
Florida has covered the spread in seven of its last eight games against top-10 AP-ranked teams at Ben Hill Griffin Stadium.
The team ranked 4th in the AP Poll has failed to cover the spread in six of its last seven games.
Florida has won the first half in each of its last 16 September games as a favorite.
Florida has won the first quarter in each of its last four games.
Why the Ole Miss Rebels will win
Florida has lost each of its last 12 games against top-5 AP-ranked teams.
Ole Miss has won each of its last seven games in September.
Florida has failed to cover the spread in seven of its last eight September games as a home favorite.
Ole Miss has covered the spread in five of its last six games against conference opponents.
Ole Miss has won the first quarter in each of its last seven games against conference opponents.
Ole Miss has won the first half in 31 of its last 33 September games as an AP-ranked team.
Total Points Facts
Eight of Florida’s last nine games as a favorite in Florida have gone UNDER the total points line.
Four of Ole Miss’ last five games as an underdog have gone OVER the total points line.
Florida Gators Player Prop Facts
Heading into Week 4, Jadan Baugh ranks T1st amongst FBS players for touchdowns (8) this season.
Ole Miss Rebels Player Prop Facts
Trinidad Chambliss has recorded a 130.0+ passer rating in nine consecutive games – equal-longest streak in the FBS.
Matchup/League Facts
Florida ranks 1st among FBS teams for Q2 points per game this season (23.0).
Florida ranks T1st among FBS teams for red zone percentage this season (100.0).
Ole Miss ranks T1st among FBS teams for red zone percentage this season (100.0).
Ole Miss ranks 135th among FBS teams for Q3 opponent points per game this season (12.7).
Ole Miss Rebels vs. Florida Gators Prediction
I’m on the over in this one. I get the case to be made for either side in this game, but I think this ends up being a bit of a high-profile shootout between two top-tier programs. I’ll admit I’m not the biggest Aaron Philo fan, but Buster Faulkner’s unlocked something with him, and Chambliss could very well be the best quarterback in the country. I’ll rock with the over in what should be a wildly entertaining affair.
