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Oklahoma State vs Iowa State Prediction 10/31/2026 Today’s College Football Picks

Oct 24, 2026; Tucson, Arizona, USA;  Iowa State Cyclones running back Aiden Flora (21) is tackled during the third quarter against the Arizona Wildcats at Casino Del Sol Stadium.  Mandatory Credit: Aryanna Frank-Imagn Images

Oct 24, 2026; Tucson, Arizona, USA; Iowa State Cyclones running back Aiden Flora (21) is tackled during the third quarter against the Arizona Wildcats at Casino Del Sol Stadium. Mandatory Credit: Aryanna Frank-Imagn Images

Oklahoma State vs Iowa State Odds and Matchup Info
MATCHUP Oklahoma State Cowboys Iowa State Cyclones
Team Records 5-2 3-4
Spread -9.5 -118 +9.5 -102
Moneyline -355 +280
Total Over 57.5 (-115) Under 57.5 (-105)
Where Jack Trice Stadium, Ames, IA
When Saturday, October 31, 2026
Time 07:00 PM EDT
TV Fox

Oklahoma State vs Iowa State Prediction


As I said in previous write-ups, Iowa State used to be a worthwhile underdog that could pull an upset or two. Iowa State is 0-3 SU and ATS in its last three games as an underdog and has lost those games by an average of 21.3 points. Iowa State doesn’t have the offensive horses to keep up with Oklahoma State as it’s 109th in total offense, 123rd in passing offense, and 90th in scoring offense.

Oklahoma State has also covered nine of its last 10 games, making the Cowboys one of the safest bets in college football dating back to last season. It’s a big number for a road team. I get it. I’m still laying the points with OK State, as this is a bad matchup for Iowa State across the board.

Oklahoma State Cowboys Betting Preview


The Oklahoma State Cowboys lost to Houston, beat Colorado, and they play Kansas State next. Oklahoma State has won 5 of its last 6 games. Drew Meskimen is completing 65.7 percent of his passes for 2,326 yards, 20 touchdowns, and 6 interceptions. Justin Bowick and Wyatt Young have combined for 1,246 receiving yards and 13 touchdowns, while Miles Coleman has 22 receptions.

The Oklahoma State Cowboys’ ground game is averaging 188.1 yards per contest, and Caleb Hawkins leads the way with 712 yards and 2 touchdowns. Defensively, Oklahoma State is allowing 23.7 points and 364 yards per game. Ethan Wesloski leads the Oklahoma State Cowboys with 70 tackles, Malik Charles has 3.5 sacks, and LaDainian Fields has 4 interceptions.

Iowa State Cyclones Betting Preview


The Iowa State Cyclones lost to BYU and Arizona, and they play Baylor next. Iowa State has lost 3 of its last 4 games. Jaylen Raynor is completing 58.9 percent of his passes for 1,107 yards, 7 touchdowns, and 4 interceptions. Dominic Overby and Omari Hayes have combined for 449 receiving yards and 2 touchdowns, while Cody Jackson has 11 receptions.

The Iowa State Cyclones’ ground game is averaging 163 yards per contest, and Aiden Flora leads the way with 716 yards and 6 touchdowns. Defensively, Iowa State is allowing 24.1 points and 370.1 yards per game. Sullivan Schlimgen leads the Iowa State Cyclones with 71 tackles, Isaac Terell has 3 sacks, and Beni Ngoyi has 1 interception.

Why the Iowa State Cyclones will win

Why the Oklahoma State Cowboys will win

Total Points Facts

Iowa State Cyclones Player Prop Facts

Oklahoma State Cowboys Player Prop Facts

Matchup/League Facts

Randy Chambers's Pick: Oklahoma State -9.5

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