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Oklahoma State vs Houston Prediction 10/17/2026 Today’s College Football Picks

Oct 10, 2026; Stillwater, Oklahoma, USA;  Oklahoma State Cowboys wide receiver Chris Barnes (2) runs the ball after a reception during the second half against the UCF Knights at Boone Pickens Stadium.  Mandatory Credit: William Purnell-Imagn Images

Oct 10, 2026; Stillwater, Oklahoma, USA; Oklahoma State Cowboys wide receiver Chris Barnes (2) runs the ball after a reception during the second half against the UCF Knights at Boone Pickens Stadium. Mandatory Credit: William Purnell-Imagn Images

MATCHUP Oklahoma State Cowboys Houston Cougars
Team Records 4-1 5-1
Spread +4.5 -110 -4.5 -110
Moneyline +160 -192
Total Over 62.5 (-110) Under 62.5 (-110)
Where TDECU Stadium, Houston, TX
When Saturday, October 17, 2026
Time 07:30 PM EDT
TV Fox

The Oklahoma State Cowboys and the Houston Cougars meet in week 7 college football action from 
TDECU Stadium on Saturday. We will look at this from a betting perspective and determine the best bets for this game. Here’s an Oklahoma State Cowboys vs. Houston Cougars Prediction.

Oklahoma State Cowboys Recap

The Oklahoma State Cowboys come into this game looking to add on to their 42-28 win over UCF last time out to sit at 4-1 this season. After this game, Oklahoma State will head home for a game against Colorado.

Cowboys Win 4 Straight

Drew Mestemaker has thrown for 1,575 yards, 13 touchdowns and 5 interceptions on 67.5% passing while Caleb Hawkins leads Oklahoma State in rushing with 524 yards and 2 touchdowns. Ayo Adeyi sits behind Hawkins on the ground with 180 yards. Wyatt Young leads the Cowboys in receiving with 462 yards and 27 catches along with 4 touchdowns, while Justin Bowick trails with 442 yards and 26 catches along with 5 touchdowns. On defense, Ethan Wesloski has a team-high 53 tackles while Oklahoma State’s defense as a whole has combined for 4 sacks and 5 interceptions.

Houston Cougars Recap

The Houston Cougars come into this game looking to add on to their 35-16 win over Kansas State last time out to sit at 5-1 this season. After this game, Houston will head on the road for a game against Utah.

Cougars Win 3 In A Row

Conner Weigman has thrown for 1,428 yards, 15 touchdowns and an interception on 66.7% passing while Re’Shaun Sanford II leads Houston in rushing with 404 yards and 2 touchdowns. Makhi Hughes sits behind Sanford II on the ground with 387 yards and 3 touchdowns. Patrick Overmyer leads the Cougars in receiving with 400 yards and 33 catches along with 6 touchdowns, while Amare Thomas trails with 361 yards and 29 catches along with 4 touchdowns. On defense, Kentrell Webb has a team-high 38 tackles while Houston’s defense as a whole has combined for 12 sacks and 5 interceptions.

Oklahoma State Cowboys @ Houston Cougars Betting Trends: Week 7

 

Why the Houston Cougars will win

Why the Oklahoma State Cowboys will win

Total Points Facts

Houston Cougars Player Prop Facts

Oklahoma State Cowboys Player Prop Facts

Matchup/League Facts

Oklahoma State Cowboys vs. Houston Cougars Prediction

I’m on Houston in this one. This will be a great matchup between two teams realy looking to put their stamp on the Big 12 this season, but I think I’m left more impressed with Houston from an all-around perspective, rather than OK State who just looks like they can flat out outscore teams but leave a bit to be desired when it comes to their defense. I think Houston delivers in a big statement spot at home so give me Houston.

Chris Ruffolo's Pick: Houston -4.5

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