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New Mexico vs Oklahoma Prediction 9/19/2026 Today’s College Football Picks

Sep 13, 2025; Philadelphia, Pennsylvania, USA; Oklahoma Sooners quarterback John Mateer (10) drops back to throw against the Temple Owls in the second half at Lincoln Financial Field. Mandatory Credit: Kyle Ross-Imagn Images

Sep 13, 2025; Philadelphia, Pennsylvania, USA; Oklahoma Sooners quarterback John Mateer (10) drops back to throw against the Temple Owls in the second half at Lincoln Financial Field. Mandatory Credit: Kyle Ross-Imagn Images

MATCHUP New Mexico Lobos Oklahoma Sooners
Team Records 2-0 1-1
Spread +21.5 -112 -21.5 -108
Moneyline +1000 -1800
Total Over 44.5 (-115) Under 44.5 (-105)
Where Memorial Stadium (Norman, OK), Norman, OK
When Saturday, September 19, 2026
Time 07:30 PM EDT
TV ESPN2
In this article we will formulate a New Mexico vs Oklahoma prediction for this College Football game on Saturday, September 19th at Memorial Stadium in Norman, Oklahoma. Let’s take a look at the prediction for this Week 3 matchup. 

New Mexico Lobos Betting Preview

The New Mexico Lobos are 2-0 this season after they defeated Mercyhurst by a score of 70-7 in week two. New Mexico led 49-7 at halftime and they won the second half 21-0 for the blowout victory. The Lobos out gained Mercyhurst by a total of 460-155, went 5-13 on third downs, and won the turnover battle by a total of 6-0 in the game. Toa Fa’avae threw for 91 yards and two touchdowns, while Troy Omeire caught two passes for 70 yards and one score. Scottre Humphrey rushed 15 times for 110 yards and two touchdowns in the win. 

Prior to that game, New Mexico defeated Central Michigan by a score of 38-7 in week one. The Lobos have scored 54.0 points per game with 166.0 passing yards and 246.0 rushing yards per game, while they have allowed 7.0 points against per game this season. Luke Moga has thrown for 198 yards, three touchdowns, and zero interceptions, while Cade Keith has five catches for 91 yards and one score. Scottre Humphrey has rushed 28 times for 174 yards and three touchdowns this season. 

Oklahoma Sooners Betting Preview

The Oklahoma Sooners are 1-1 this year after they lost to Michigan by a score of 17-10 last week. Oklahoma trailed 10-0 at halftime, but they tied the game 10-10 in the fourth, before allowing a score with about eight minutes left for the loss. The Sooners out gained Michigan by a total of 289-263, went 3-13 on third downs, and lost the turnover battle by a total of 2-0 in the game. John Mateer threw for 189 yards, one touchdown, and one interception, while Rocky Beers caught six passes for 94 yards. Mateer also led the ground game with 45 yards on 13 carries. 

Prior to that loss, Oklahoma defeated UTEP by a score of 51-0 in week one. The Sooners have scored 30.5 points per game with 210.0 passing yards and 135.0 rushing yards per game, while they have allowed 8.5 points against per game this season. John Mateer has thrown for 414 yards, four touchdowns, and one interception, while Lloyd Avant has rushed 24 times for 114 yards and one score this year. 

Why the Oklahoma Sooners will win

Why the New Mexico Lobos will win

Total Points Facts

Oklahoma Sooners Player Prop Facts

New Mexico Lobos Player Prop Facts

Matchup/League Facts

New Mexico vs Oklahoma Prediction 

Oklahoma comes into this matchup after a disappointing offensive effort against Michigan, but they will be back at home. The Sooners have played great defense through two games and they scored 51 points against UTEP in their opener. New Mexico is 2-0 and they have allowed a total of 14 points, but they have played a very easy schedule so far. The Lobos have some issues at quarterback and I don’t see them scoring much here. Take Oklahoma to cover in this one.

David Racey's Pick: Oklahoma -21.5

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