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Missouri vs Ole Miss Prediction 10/17/2026 Today’s College Football Picks

Oct 10, 2026; Nashville, Tennessee, USA;  Mississippi Rebels running back Kewan Lacy (5) celebrates his touchdown against the Vanderbilt Commodores during the first half at FirstBank Stadium. Mandatory Credit: Steve Roberts-Imagn Images

Oct 10, 2026; Nashville, Tennessee, USA; Mississippi Rebels running back Kewan Lacy (5) celebrates his touchdown against the Vanderbilt Commodores during the first half at FirstBank Stadium. Mandatory Credit: Steve Roberts-Imagn Images

MATCHUP Missouri Tigers Ole Miss Rebels
Team Records 5-1 4-1
Spread +5.5 -110 -5.5 -110
Moneyline +185 -225
Total Over 58.5 (-112) Under 58.5 (-108)
Where Vaught-Hemingway Stadium, Oxford, MS
When Saturday, October 17, 2026
Time 03:30 PM EDT
TV SEC Network

The Missouri Tigers and Ole Miss Rebels meet Saturday in week 7 college football action at Vaught-Hemingway Stadium. Here’s a Missouri vs. Ole Miss Prediction. This article will include a Missouri vs. Ole Miss Pick.

Missouri Tigers Betting Preview

The Missouri Tigers beat Florida and Texas A&M, and they play Arkansas next. The Missouri Tigers have won 7 of their last 10 games. Austin Simmons is completing 64.8 percent of his passes for 1,434 yards, 14 touchdowns, and 1 interception. Donovan Olugbode and Cayden Lee have combined for 1,023 receiving yards and 11 touchdowns, while Shaun Terry II has 9 receptions.

The Missouri Tigers’ ground game is averaging 182.5 yards per contest, and Jamal Roberts leads the way with 828 yards and 8 touchdowns. Defensively, Missouri is allowing 17.7 points and 302.5 yards per game. Nicholas Rodriguez leads the Missouri Tigers with 63 tackles, Daeden Hopkins has 7 sacks, and Trajen Greco has 2 interceptions.

Ole Miss Rebels Betting Preview

The Ole Miss Rebels lost to Florida, beat Vanderbilt, and they play Texas next. The Ole Miss Rebels have won 11 of their last 13 games. Austin Simmons is completing 70.1 percent of his passes for 1,435 yards, 11 touchdowns, and 4 interceptions. Traylon Ray and Deuce Alexander have combined for 734 receiving yards and 6 touchdowns, while Caleb Odom has 17 receptions.

The Ole Miss Rebels’ ground game is averaging 133.2 yards per contest, and Kewan Lacy leads the way with 230 yards and 5 touchdowns. Defensively, Ole Miss is allowing 28 points and 392.4 yards per game. Luke Ferrelli leads the Ole Miss Rebels with 34 tackles, Blake Purchase has 3.5 sacks, and Nick Cull has 2 interceptions.

Why the Ole Miss Rebels will win

Why the Missouri Tigers will win

Total Points Facts

Ole Miss Rebels Player Prop Facts

Missouri Tigers Player Prop Facts

Matchup/League Facts

Missouri vs Ole Miss Prediction

Ole Miss should get the benefit of the doubt at home, and Missouri still has some showing and proving to do on the road. However, Missouri is a tough-nosed team with a balanced offense and a defense that stops the run. It’s not always pretty, but Missouri has the formula to beat anybody on any given week and looks like a live dog in this spot. Move the chains, stop the run, and Missouri can grind this thing out with a chance to steal it late. Give me the points.

Randy Chambers's Pick: Missouri +5.5

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