Colorado vs Oklahoma State Prediction 10/24/2026 Today’s College Football Picks
Chris Ruffolo
OSU quarterback Drew Mestemaker (17) warms up before an NCAA football game between the Oklahoma State University (OSU) Cowboys and the University of Central Florida (UCF) Knights at Boone Pickens Stadium in Stillwater, Okla., on Saturday, Oct. 10, 2026.
Colorado vs Oklahoma State Odds and Matchup Info
MATCHUP
Colorado Buffaloes
Oklahoma State Cowboys
Team Records
2-4
4-2
Spread
+13.5 -115
-13.5 -105
Moneyline
+410
-550
Total
Over 56.5 (-108)
Under 56.5 (-112)
Where
Boone Pickens Stadium, Stillwater, OK
When
Saturday, October 24, 2026
Time
07:00 PM EDT
TV
FS1
The Colorado Buffaloes and the Oklahoma State Cowboys meet in week 8 college football action from Boone Pickens Stadium on Saturday. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Colorado Buffaloes vs. Oklahoma State Cowboys Prediction.
Colorado Buffaloes Recap
The Colorado Buffaloes come into this game looking to bounce back from their 27-24 loss at the hands of Utah last time out to sit at 2-4 this season. After this game, Colorado will take on Kansas State in a matchup at home.
Buffaloes Lose 4th In A Row
Julian Lewis has thrown for 733 yards, 6 touchdowns and 2 interceptions on 64.2% passing while JaQuail Smith leads Colorado in rushing with 259 yards. Micah Welch sits behind Smith on the ground with 220 yards and 2 touchdowns. Joseph Williams leads the Buffaloes in receiving with 508 yards and 37 catches along with 5 touchdowns, while DeAndre Moore Jr. trails with 312 yards and 23 catches along with 2 touchdowns. On defense, Randon Fontenette has a team-high 51 tackles while Colorado’s defense as a whole has combined for 14 sacks and 4 interceptions.
Oklahoma State Cowboys Recap
The Oklahoma State Cowboys come into this game looking to bounce back from their 35-32 loss at the hands of Houston last time out to sit at 4-2 this season. After this game, Oklahoma State will head on the road for a game against Iowa State.
Cowboys Have Four-Game Win Streak Snapped
Drew Mestemaker has thrown for 1,575 yards, 13 touchdowns and 5 interceptions on 67.5% passing while Caleb Hawkins leads Oklahoma State in rushing with 524 yards and 2 touchdowns. Ayo Adeyi sits behind Hawkins on the ground with 180 yards. Wyatt Young leads the Cowboys in receiving with 462 yards and 27 catches along with 4 touchdowns, while Justin Bowick trails with 442 yards and 26 catches along with 5 touchdowns. On defense, Ethan Wesloski has a team-high 53 tackles while Oklahoma State’s defense as a whole has combined for 4 sacks and 5 interceptions.
Colorado Buffaloes vs. Oklahoma State Cowboys Prediction
I’m on Oklahoma State here. I just don’t think that Colorado has the QB play to go shot for shot with Oklahoma State in this one, and with both teams coming off of a loss, I expect OK State to be more focused here while Colorado put everything into that home run effort against Utah last week. Give me OK State at home here.
