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Colorado State vs UTSA Prediction 9/26/2026 Today’s College Football Picks

Nov 6, 2025; Tampa, Florida, USA; UTSA Roadrunners wide receiver Mekhi Anderson (33) runs the ball in for a touchdown against the South Florida Bulls  during the second half at Raymond James Stadium. Mandatory Credit: Kim Klement Neitzel-Imagn Images

Nov 6, 2025; Tampa, Florida, USA; UTSA Roadrunners wide receiver Mekhi Anderson (33) runs the ball in for a touchdown against the South Florida Bulls during the second half at Raymond James Stadium. Mandatory Credit: Kim Klement Neitzel-Imagn Images

MATCHUP Colorado State Rams UTSA Roadrunners
Team Records 2-1 2-1
Spread +13.5 -108 -13.5 -112
Moneyline +425 -575
Total Over 58.5 (-105) Under 58.5 (-115)
Where Alamodome, San Antonio, TX
When Saturday, September 26, 2026
Time 12:00 PM EDT
TV ESPNU
The Colorado State Rams and UTSA Roadrunners meet Saturday in week 4 college football action at Alamodome. Here’s a Colorado State vs. UTSA Prediction. This article will include a Colorado State vs. UTSA Pick.

Colorado State Rams Betting Preview


The Colorado State Rams beat Southern Utah, lost to BYU, and they play Oregon State next. Colorado State has lost 10 of its last 13 games. Hauss Hejny is completing 64.4 percent of his passes for 619 yards, 10 touchdowns, and 1 interception. Cedric Ross and RJ Vick have combined for 353 receiving yards and 6 touchdowns, while Jackson Harper has 12 receptions.

The Colorado State Rams ground game averages 177.3 yards per contest, and Mel Brown leads with 256 yards and 2 touchdowns. Defensively, Colorado State is allowing 26 points and 424.7 yards per game. Tre’Shawn Moore leads the Colorado State Rams with 25 tackles, Elijah Brown has 1.5 sacks, and CJ Blocker has 3 interceptions.

UTSA Roadrunners Betting Preview


The UTSA Roadrunners beat Texas State, lost to Texas, and play Rice next. UTSA has won 5 of its last 7 games. Owen McCown is completing 69.6 percent of his passes for 559 yards, 4 touchdowns, and 1 interception. DJ Allen Jr. and Mekhi Anderson have combined for 289 receiving yards and 2 touchdowns, while AJ Wilson has 12 receptions.

The UTSA Roadrunners’ ground game is averaging 154.7 yards per contest, and Will Henderson III leads the way with 219 yards and 1 touchdown. Defensively, UTSA is allowing 24 points and 434.3 yards per game. Brandon Tucker leads the UTSA Roadrunners with 29 tackles, James Walley Jr. has 1 sack, and Ahamad Chapman has 1 interception.

Why the UTSA Roadrunners will win

Why the Colorado State Rams will win

Total Points Facts

UTSA Roadrunners Player Prop Facts

Colorado State Rams Player Prop Facts

Matchup/League Facts

Colorado State vs UTSA Prediction


Colorado State has had issues in recent years stepping up in competition, and this defense doesn’t make me believe things will change. Colorado State can’t stop the run and is 120th overall in total defense. UTSA beat a talented Texas State team on the road and covered against Texas. UTSA couldn’t do much offensively against the Longhorns, but many teams would have lost in worse fashion. UTSA has been sneaky good up to this point. I’ll lay the number just inside two full touchdowns.

Randy Chambers's Pick: UTSA -13.5

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