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South Carolina vs Butler Prediction 11/21/2025 Today’s College Basketball Picks

Butler Bulldogs guard Finley Bizjack (11) brings the ball up court during the first half of an NCAA basketball game against the Southern Indiana Screaming Eagles, Wednesday, Nov. 5, 2025, at Hinkle Fieldhouse.

Butler Bulldogs guard Finley Bizjack (11) brings the ball up court during the first half of an NCAA basketball game against the Southern Indiana Screaming Eagles, Wednesday, Nov. 5, 2025, at Hinkle Fieldhouse.

MATCHUP Butler Bulldogs South Carolina Gamecocks
Team Records 4-1 4-1
Where Colonial Hall, White Sulphur Springs, WV
When Friday, November 21, 2025
Time 02:00 PM EST
TV CBSSN

The South Carolina Gamecocks and the Butler Bulldogs meet Friday in college basketball action from the Colonial Hall. We will look at this from a betting perspective and determine the best bets for this game. Here’s a South Carolina Gamecocks vs. Butler Bulldogs prediction.

South Carolina Gamecocks Recap

The South Carolina Gamecocks come into this game looking to build on an 87-58 win over Radford last time out to sit at 4-0 on the year. After this game, South Carolina will take on Northwestern.

Gamecocks Looking To Stay Unbeaten

Meechie Johnson leads the Gamecocks in scoring and assists with 14.5 PPG and 3.8 APG while Eli Ellis has 13.5 PPG with 3.5 RPG and 3.8 APG of his own this season. Mike Sharavjamts has 11.5 PPG with a team-high 6 RPG to cap off the group of double-digit scorers for South Carolina so far this season. Myles Stute also has 8.8 PPG with 4 RPG and Kobe Knox has 7.8 PPG with 3.5 APG this season. As a team, South Carolina is averaging 85.5 PPG on 46.9% shooting from the field, 36% from three and 77.5% from the foul line this season.

Butler Bulldogs Recap

The Butler Bulldogs come into this game looking to bounce back from an 87-85 loss at the hands of SMU last time out to sit at 3-1 this season. After this game, Butler will square off against Virginia.

Bulldogs Coming Off Of First L

Finley Bizjack leads the Bulldogs in scoring with 15 PPG and 3.3 APG while Michael Ajayi has 14.8 PPG with a team-high 11.8 RPG and 4 APG to lead the Bulldogs in rebounding by averaging a double-double per game. Jamie Kaiser Jr. has 11.5 PPG with 5 RPG and Yohan Traore has 10 PPG with 3.3 RPG to cap off the group of double-digit scorers for Butler up to this point in the year. Jalen Jackson has 9.3 PPG with 3.8 RPG and 4.8 APG to lead the Butler Bulldogs in assists this season. As a team, Butler is averaging 95.8 PPG on 49% shooting from the field, 40.2% from three and 67.2% from the foul line this season.

South Carolina Gamecocks @ Butler Bulldogs Betting Trends: November 21, 2025

Why the Butler Bulldogs will win

Why the South Carolina Gamecocks will win

Total Points Facts

Matchup/League Facts

South Carolina Gamecocks vs. Butler Bulldogs Prediction

I’m on the Bulldogs here. I just think it’s telling that Butler is favored here, and to be honest I think these teams are even offensively, but I don’t think that South Carolina has an answer on the boards for Ajayi and I think that the second chances for Butler loom large here as Butler snags the win and cover in this one. Give me Butler.

Chris Ruffolo's Pick: Butler -2.5

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