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SMU vs Louisville Prediction 3/11/2026 Today’s College Basketball Picks

Mar 10, 2026; Charlotte, NC, USA; Southern Methodist University Mustangs center Samet Yigitoglu (24) and guard Boopie Miller (2) with head coach Andy Enfield in the second half at Spectrum Center. Mandatory Credit: Bob Donnan-Imagn Images

Mar 10, 2026; Charlotte, NC, USA; Southern Methodist University Mustangs center Samet Yigitoglu (24) and guard Boopie Miller (2) with head coach Andy Enfield in the second half at Spectrum Center. Mandatory Credit: Bob Donnan-Imagn Images

MATCHUP SMU Mustangs Louisville Cardinals
Team Records 20-12 22-9
Spread +6.5 -110 -6.5 -110
Moneyline +220 -270
Total Over 163.5 (-112) Under 163.5 (-108)
Where Madison Square Garden, New York, NY
When Wednesday, March 11, 2026
Time 02:30 PM EDT
TV ESPN
In this article we will formulate a SMU vs Louisville prediction for this College Basketball game on Wednesday, March 11th at the Spectrum Center in Charlotte, North Carolina. Let’s take a look at the prediction for this College Basketball matchup.

SMU Mustangs Betting Preview

The SMU Mustangs are 20-12 (8-10) this season after they defeated Syracuse by a score of 86-69 in their last game. SMU led 39-38 at halftime and they scored 47 points in the second half for the easy win. The Mustangs shot 47% from the field, 33% on three pointers, and 88% on free throws in the game. Boopie Miller led SMU with 25 points and seven rebounds, while Jaron Pierre Jr added 21 points and five rebounds in the win. 

Prior to that game, SMU lost to Florida State by a score of 91-78 and Miami by a score of 77-69. The Mustangs have scored 85.0 points per game with 37.6 rebounds and 17.1 assists per game, while they have allowed 78.4 points against per game this season. Boopie Miller is averaging 19.4 points and 6.6 assists per game, while Jaron Pierre Jr is averaging 17.5 points and 5.0 rebounds per game for the Mustangs. SMU is shooting 49.3% from the field, 74.2% on free throws, and 37.8% on three pointers this season. 

Louisville Cardinals Betting Preview

The Louisville Cardinals are 22-9 (11-7) this year after they defeated Miami by a score of 92-89 in their last game. Louisville led 46-37 at halftime, but they were outscored 52-46 in the second half in the win. The Cardinals shot 60% from the field, 50% on three pointers, and 67% on free throws in the game. Ryan Conwell led Louisville with 24 points and two assists, while J’Vonne Hadley added 16 points and two rebounds in the win. 

Prior to that game, Louisville defeated Syracuse by a score of 77-62, but did lose to Clemson by a score of 80-75 before that. The Cardinals have scored 85.9 points per game with 38.7 rebounds and 17.4 assists per game, while they have allowed 72.5 points against per game this season. Ryan Conwell is averaging 18.7 points and 4.7 rebounds per game, while Mikel Brown Jr. (OUT) is averaging 18.2 points and 4.7 assists per game for the Cardinals. Louisville is shooting 47.2% from the field, 77.1% on free throws, and 36.3% on three pointers this season. 

Why the Louisville Cardinals will win

Why the SMU Mustangs will win

Total Points Facts

Matchup/League Facts

SMU vs Louisville Prediction 

SMU comes into this matchup after snapping their losing streak with a win on Tuesday, but they have really struggled over the last few weeks. The Mustangs are shooting 49% from the field and they have allowed 77+ points in three of their last four. Louisville has won two in a row, but they are missing their second leading scorer. The Cardinals are shooting 47% from the field and they have allowed 77+ in three of their last four. I really dislike how SMU plays defense, but I think they can win this game with Brown Jr. out. Take SMU and the points here.

David Racey's Pick: SMU +6.5

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